Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial.

Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial. Abstract Text:

J Li,H Tian,Q Li,N Wang,T Wu,Y Liu,Z Ni,H Yu,J Liang,R Luo,Y Li,L Huang,J Li,H Tian,Q Li,N Wang,T Wu,Y Liu,Z Ni,H Yu,J Liang,R Luo,Y Li,L Huang,

AIM: To evaluate the efficacy of nateglinide vs. repaglinide in blood glucose (BG) control and the effect on insulin resistance and beta-Cell function in patients with type 2 diabetes. METHODS: A randomized controlled double-blind and double-dummy multicentre clinical trial was conducted. A total of 230 Chinese patients with type 2 diabetes were enrolled in five clinical centres. The patients were divided randomly into group A [repaglinide 1.0 mg three times daily (t.i.d.), n = 115] or group B (nateglinide 90 mg t.i.d., n = 115). At baseline and end of the 12-week clinical trial, standard mixed meal tolerance tests were performed. RESULTS: A total of 223 patients (96.9%) completed the trial. There was no significant difference between repaglinide and nateglinide groups in the effects of reducing fasting blood glucose (FBG), 30-, 60- and 120-min BG during 12 weeks (p > 0.05). At week 12, no significant difference was shown between the two groups in BG or haemoglobin A(1c) (HbA(1c)) (p > 0.05). However, the effect on HbA(1c) in repaglinide group was stronger than that in nateglinide group (p < 0.05). After 12-week treatment, area under the curve (AUC) of BG decreased (p < 0.05), and AUC of insulin and C-peptide (CP) increased in both groups (p < 0.05). The effects of nateglinide on AUC of BG, insulin and CP were similar to that of repaglinide (p > 0.05). There was no significant difference between the two groups in AUC of BG, insulin or CP in week 12 (p > 0.05). Furthermore, homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function indexes measured by HOMA-beta, DeltaI(30)/DeltaG(30) and (DeltaI(30)/DeltaG(30))/HOMA-IR were improved significantly in both groups during 12 weeks (p < 0.05). The effects of improving HOMA-IR and beta-cell function indexes in nateglinide group were comparable with that of repaglinide group (p > 0.05). CONCLUSIONS: The efficacy of repaglinide and nateglinide in FBG, postprandial glucose excursion and early-phase insulin secretion is similar. But the effect of repaglinide 1.0 mg t.i.d. on HbA(1c) is stronger than that of nateglinide 90 mg t.i.d.. This trial had shown that nateglinide and repaglinide could comparably improve insulin sensitivity and beta-cell function.

Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial. Publishing Authors By Initials

J Li,H Tian,Q Li,N Wang,T Wu,Y Liu,Z Ni,H Yu,J Liang,R Luo,Y Li,L Huang,J Li,H Tian,Q Li,N Wang,T Wu,Y Liu,Z Ni,H Yu,J Liang,R Luo,Y Li,L Huang,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Diabetes, obesity & metabolism

VOLUME: 9

Page Numbers: 558-65

Journal Abbreviation:

ISSN: 1462-8902

DAY: 25

MONTH: Jul

YEAR: 2007

Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100883645

Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial.

AFFILIATION: Department of Endocrinology, State Key Lab of Biotherapy, West China Hospital of Sichuan University, Chengdu, China.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Diabetes Obes Metab

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial Related Publications

• Clinicopathological observation of renal adenomas.
• Effects of the central amygdaloid nucleus lesions on the gustatory responses in the parabrachial nucleus in rats.
• Ehlers-Danlos syndrome: case and pedigree report and review.
• Telangiectatic osteosarcoma: a clinicopathologic analysis of 14 cases.
• [A rapid and simple detection of DNA fragment with point mutation by capillary electrophoresis]
• [A simple and rapid new method for SNP typing by single-tube bi-directional allele specific amplification]
• [Algorithms of multiband remote sensing for coastal red tide waters]
• [Analysis of factors correlated to death and reinfarction in patients with acute myocardial infarction]
• [Application of liposuction in scar repair]
• [Biomechanical evaluation of the stability of General spine system]
• [Clinical analysis of combined resection for T4 gastric cancer: report of 69 cases]
• [Determination of residues of organic chloride pesticide in Chinese Medicinal materials with capillary gas chromatography]
• [Ecological characteristics of Prorocentrum dentatum and the cause of harmful algal bloom formation in China Sea]
• [Effect of intracerebroventricular injection of histamine on carotid sinus baroreceptor reflex in anesthetized rats and its mechanism]
• [Experience with cardioventer defibrillator therapy in 113 patients]
• [Lower back pain in truck drivers working in plateau areas and its prevention]
• [Mammographic findings of gynecomastia]
• [Miniature quadrupole mass spectrometer array and its applications in manned spaceflight]
• [Molecular identification of human/goat xenogeneic model]
• [Phosphorylated JNK mediated apoptosis induced by all trans retinoid acid in human retinoblastoma cell line]
• [Protective effects of c-jun anti-sense gene recombinant transfection on rat cardiomyocytes inflicted by hypoxia and burn serum]
• [Purification and stability studies of prokaryotic PDCD5 protein]
• [Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction]
• [Repair of facial defect with expanded skin flap from medial upper arm]
• [Secondary reconstruction of post-fracture deformities in the nasal-orbital ethmoid region]
• [Study on morphological change in intestinal mucosa from injury to repair after hemorrhagic shock]
• [Study on the therapeutic effect of combined use of obidoxime and atropine with respiratory machine on respiratory muscle paralysis caused by omethoate poisoning of rats]
• [The correlations between glucocorticoid receptor of lymphocyte and immune function]
• [The reason and prevention of upper cervical reoperations]
• [The relation and evaluation of the vertebral artery and the nerve root to posterior lateral mass screw fixation]