Improvement in memory and static balance with abstinence in alcoholic men and women: selective relations with change in brain structure.

Improvement in memory and static balance with abstinence in alcoholic men and women: selective relations with change in brain structure. Research Abstract Details 

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Improvement in memory and static balance with abstinence in alcoholic men and women: selective relations with change in brain structure. Abstract Text:

Margaret J Rosenbloom,Torsten Rohlfing,Anne W O'Reilly,Stephanie A Sassoon,Adolf Pfefferbaum,Edith V Sullivan,

We investigated whether changes in memory or static balance in chronic alcoholics, occurring with abstinence or relapse, are associated with changes in lateral and fourth ventricular volume. Alcoholics meeting DSM-IV criteria for Alcohol Dependence (n=15) and non-alcoholic controls (n=26) were examined twice at a mean interval of 2 years with standard Wechsler Abbreviated Scale of Intelligence (WASI), Wechsler Memory Scale-Revised (WMS-R) tests, an ataxia battery, and structural MRI. At study entry, alcoholics had been abstinent on average for over 4 months and achieved lower scores than controls on WASI General IQ Index, WMS-R General Memory Index, and the ataxia battery. The 10 alcoholics who maintained sobriety at retest did not differ at study entry in socio-demographic measures, alcohol use, or WASI and WMS-R summary scores from the five relapsers. At follow-up, abstainers improved more than controls on the WMS-R General Memory Index. Ataxia tended to improve in abstainers relative to controls. Associations were observed between memory and lateral ventricular volume change and between ataxia and fourth ventricular volume change in alcoholics but not in the controls. Both memory and ataxia can improve with sustained sobriety, and brain-behavior associations suggest selective brain structural substrates for the changes observed.

Improvement in memory and static balance with abstinence in alcoholic men and women: selective relations with change in brain structure. Publishing Authors By Initials

MJ Rosenbloom,T Rohlfing,AW O'Reilly,SA Sassoon,A Pfefferbaum,EV Sullivan,

For similar human activities: temperance research abstracts see: human activities: temperance research

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Improvement in memory and static balance with abstinence in alcoholic men and women: selective relations with change in brain structure. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Psychiatry research

VOLUME: 155

Page Numbers: 91-102

Journal Abbreviation:

ISSN: 0165-1781

DAY: 3

MONTH: 04

YEAR: 2007

Improvement in memory and static balance with abstinence in alcoholic men and women: selective relations with change in brain structure. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Improvement in memory and static balance with abstinence in alcoholic men and women: selective relations with change in brain structure. Keywords Mesh Terms:

KEYWORDS: Temperance

MESH TERMS: psychology

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Grant and Affiliation Information for Improvement in memory and static balance with abstinence in alcoholic men and women: selective relations with change in brain structure.

AFFILIATION: Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305-5723, USA.

Country: Ireland

AGENCY: United States NIA

GRANT: R01 AG017919-06A1

ACRONYM: AG

MEDLINETA: Psychiatry Res

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