Improved myocardial function after cold storage with preservation solution supplemented with a carbon monoxide-releasing molecule (CORM-3).

Improved myocardial function after cold storage with preservation solution supplemented with a carbon monoxide-releasing molecule (CORM-3). Research Abstract Details 

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Improved myocardial function after cold storage with preservation solution supplemented with a carbon monoxide-releasing molecule (CORM-3). Abstract Text:

Muntaser D Musameh,Colin J Green,Brian E Mann,Barry J Fuller,Roberto Motterlini,

BACKGROUND: Carbon monoxide-releasing molecules (CO-RMs) are pharmacologically active as they protect against cardiac graft rejection and cold ischemia-mediated renal dysfunction. We investigated the cardioprotective role of carbon monoxide (CO) released from CORM-3 against cold ischemia-mediated injury in the heart and evaluated its potential application in the clinical setting of cardiac transplantation. METHODS: Isolated rat hearts underwent cold ischemic storage for 4 or 6 hours using St Thomas Hospital solution that was supplemented with either CORM-3 (50 mumol/liter) or its inactive counterpart (iCORM-3), which does not release CO. Hearts were then reperfused. Both functional parameters and release of cardiac enzymes were assessed. RESULTS: Addition of CORM-3 to the preservation solution resulted in a significant improvement in systolic and diastolic function as well as coronary flow when compared with hearts treated with iCORM-3. In addition, lower levels of the cardiac enzymes creatine kinase and lactate dehydrogenase were measured in the perfusate of hearts stored with CORM-3. CONCLUSIONS: The improved functional recovery and reduced enzyme release after cardiac cold storage with CORM-3, but not iCORM-3, indicate that CO is the main mediator of myocardial protection. Thus, CO-RMs can be used as adjuvants to improve the preservation of hearts for transplantation.

Improved myocardial function after cold storage with preservation solution supplemented with a carbon monoxide-releasing molecule (CORM-3). Publishing Authors By Initials

MD Musameh,CJ Green,BE Mann,BJ Fuller,R Motterlini,

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Improved myocardial function after cold storage with preservation solution supplemented with a carbon monoxide-releasing molecule (CORM-3). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of heart and lung transplantation : th

VOLUME: 26

Page Numbers: 1192-8

Journal Abbreviation: J. Heart Lung Transplant.

ISSN: 1557-3117

DAY: 20

MONTH: Nov

YEAR: 2007

Improved myocardial function after cold storage with preservation solution supplemented with a carbon monoxide-releasing molecule (CORM-3). Information

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LANGUAGE: eng

NlmUniqueID: 9102703

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Grant and Affiliation Information for Improved myocardial function after cold storage with preservation solution supplemented with a carbon monoxide-releasing molecule (CORM-3).

AFFILIATION: Department of Surgery, Royal Free and University College London Medical School, Hampstead, London, UK.

Country: United States

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MEDLINETA: J Heart Lung Transplant

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