Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels.

Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels. Abstract Text:

Sergei Yu Noskov, Roux,

Fundamental concepts governing ion selectivity in narrow pores are reviewed and the microscopic factors responsible for the lack of selectivity of the NaK channel, which is structurally similar to the K+-selective KcsA channel, are elucidated on the basis of all-atom molecular dynamics free energy simulations. The results on NaK are contrasted and compared with previous studies of the KcsA channel. Analysis indicates that differences in hydration of the cation in the pore of NaK is at the origin of the lack of selectivity of NaK.

Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels. Publishing Authors By Initials

SY Noskov,B Roux,

For similar water research abstracts see: water research

PUBMED ID PMID:

MEDLINE DATE:

Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of general physiology

VOLUME: 129

Page Numbers: 135-43

Journal Abbreviation: J. Gen. Physiol.

ISSN: 0022-1295

DAY: 16

MONTH: 01

YEAR: 2007

Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels. Information

Number of References: 23

LANGUAGE: eng

NlmUniqueID: 2985110

Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels. Keywords Mesh Terms:

KEYWORDS: Water

MESH TERMS: chemistry

Chemical & Substance for Abstract: Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels. Information

Substance Name: Water

Registry Number: 7732-18-5

Grant and Affiliation Information for Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels.

AFFILIATION: Institute for Molecular Pediatric Sciences, Gordon Center for Integrative Sciences, University of Chicago, IL 60637, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM062342

ACRONYM: GM

MEDLINETA: J Gen Physiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels Related Publications

• A new optimization approach for the calibration of an ultrasound probe using a 3D optical localizer.
• A proton-controlled check valve for sodium ion transport.
• A review of image watermarking applications in healthcare.
• Analysing Gene Regulatory Networks by both Constraint Programming and Model-Checking.
• Anatomy of a structural pathway for activation of the catalytic domain of Src kinase Hck.
• Characterization of conformational equilibria through Hamiltonian and temperature replica-exchange simulations: assessing entropic and environmental effects.
• Correction to "solvation and polarization of the N-methyl amine molecule in aqueous solution: a combined study of quantum mechanics and integral equation theory in three dimensions" by qishi du and dongqing wei.
• Detection of lesions in retina photographs based on the wavelet transform.
• Dynamics of the Kv1.2 voltage-gated K+ channel in a membrane environment.
• Ellipsoid-Constrained Robust Fitting of Quadrics with Application to the 3D Morphological Characterization of Articular Surfaces.
• Evaluation of 3D Anatomical Surfaces Indexing for Surgery Planning.
• Fluorescent TiO2 powders prepared using a new perylene diimide dye: applications in latent fingermark detection.
• Functional association of Sun1 with nuclear pore complexes.
• Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels.
• In vivo 3D reconstruction of human vertebrae with the three-dimensional X-ray absorptiometry (3D-XA) method.
• Insertion of GPI-anchored alkaline phosphatase into supported membranes: a combined AFM and fluorescence microscopy study.
• Ion selectivity in potassium channels.
• Mixed Reversible and RONI Watermarking for Medical Image Reliability Protection.
• Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol.
• Molecular dynamics - potential of mean force calculations as a tool for understanding ion permeation and selectivity in narrow channels.
• Molecular dynamics study of hydration in ethanol-water mixtures using a polarizable force field.
• Multimedia medical case retrieval using decision trees.
• On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases.
• Prevention of volatile fatty acids production and limitation of odours from winery wastewaters by denitrification.
• The free energy landscapes governing conformational changes in a glutamate receptor ligand-binding domain.
• [Hypersensitivity of the skin to picric acid; simulation of accident.]
• [In Process Citation]
• [Not Available.]
• [Not Available.]
• d-Gallocatechin from the bark of Casuarina equisetifolia Linn.