Implications of positron emission tomography research for the investigation of the actions of antipsychotic drugs.

Implications of positron emission tomography research for the investigation of the actions of antipsychotic drugs. Research Abstract Details 

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Implications of positron emission tomography research for the investigation of the actions of antipsychotic drugs. Abstract Text:

S J List,J M Cleghorn,

Positron emission tomography studies of regional brain metabolic activity, cerebral blood flow and D2 dopamine receptor binding in schizophrenics and controls are reviewed. Methodological influences on the validity of the data generated by these technologies include problems with measurement as well as clinical and anatomical heterogeneity. Work in these fields to date, however, has produced strong support for the role of D2 dopamine receptor blockade in antipsychotic efficacy. Neuroleptic-induced changes in regional brain metabolism over time have also been observed; however, the relationship between such actions and symptomatic change needs to be further clarified. Future studies on time-course of neuroleptic-associated changes in regional brain metabolism, blood flow and dopamine receptor binding in schizophrenics have the potential to provide greater insight into the relationship of these actions to symptomatic changes and drug-induced side-effects.

Implications of positron emission tomography research for the investigation of the actions of antipsychotic drugs. Publishing Authors By Initials

SJ List,JM Cleghorn,

For similar tomography, emission-computed research abstracts see: tomography, emission-computed research

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Implications of positron emission tomography research for the investigation of the actions of antipsychotic drugs. Journal Published:

PUBLICATION TYPE: Review

Journal: The British journal of psychiatry. Supplement

VOLUME:

Page Numbers: 25-30

Journal Abbreviation:

ISSN: 0960-5371

DAY: 22

MONTH: Dec

YEAR: 1993

Implications of positron emission tomography research for the investigation of the actions of antipsychotic drugs. Information

Number of References: 46

LANGUAGE: eng

NlmUniqueID: 9001294

Implications of positron emission tomography research for the investigation of the actions of antipsychotic drugs. Keywords Mesh Terms:

KEYWORDS: Tomography, Emission-Computed

MESH TERMS: radionuclide imaging

Chemical & Substance for Abstract: Implications of positron emission tomography research for the investigation of the actions of antipsychotic drugs. Information

Substance Name: Receptors, Dopamine

Registry Number: 0

Grant and Affiliation Information for Implications of positron emission tomography research for the investigation of the actions of antipsychotic drugs.

AFFILIATION: Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Country: ENGLAND

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MEDLINETA: Br J Psychiatry Suppl

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