Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression.

Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression. Research Abstract Details 

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Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression. Abstract Text:

Major alterations of the hypothalamic-pituitary-adrenocortical (HPA) system that can be reversed by successful antidepressant therapy are often seen in depressed patients. Persuasive evidence points to the involvement of a dysfunctional glucocorticoid receptor (GR) system in these changes. Support for this also comes from studies of transgenic mice that express an antisense RNA, complementary to the GR mRNA, and have numerous neuroendocrine characteristics of human depression as well as altered behaviour. Many of these neuroendocrine and behavioural characteristics of the transgenic mice can be reversed by antidepressants. A possible explanation for this is that the antidepressant-induced increase in GRs renders the HPA axis more sensitive to glucocorticoid feedback. This new insight into antidepressant drug action suggests a novel approach to the development of antidepressant drugs.

Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression. Publishing Authors By Initials

For similar nucleic acids, nucleotides, and nucleosides: antisense elements (genetics): rna, antisense research abstracts see: nucleic acids, nucleotides, and nucleosides: antisense elements (genetics): rna, antisense research

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Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of psychiatry & neuroscience : JPN

VOLUME: 29

Page Numbers: 185-93

Journal Abbreviation: J Psychiatry Neurosci

ISSN: 1180-4882

DAY: 6

MONTH: May

YEAR: 2004

Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression. Information

Number of References: 94

LANGUAGE: eng

NlmUniqueID: 9107859

Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression. Keywords Mesh Terms:

KEYWORDS: RNA, Antisense

MESH TERMS: genetics

Chemical & Substance for Abstract: Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression. Information

Substance Name: RNA, Antisense

Registry Number: 0

Grant and Affiliation Information for Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression.

AFFILIATION: Neuroscience Research Department, Centre Hospitalier de l'Université Laval Research Centre, Sainte-Foy, QC. barden@crchul.ulaval.ca

Country: Canada

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MEDLINETA: J Psychiatry Neurosci

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