Implantation study of a novel hydroxyapatite/collagen (HAp/col) composite into weight-bearing sites of dogs.

Implantation study of a novel hydroxyapatite/collagen (HAp/col) composite into weight-bearing sites of dogs. Research Abstract Details 

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Implantation study of a novel hydroxyapatite/collagen (HAp/col) composite into weight-bearing sites of dogs. Abstract Text:

Soichiro Itoh,Masanori Kikuchi,Kazuo Takakuda,Katsuyoshi Nagaoka,Yoshihisa Koyama,Junzo Tanaka,Kenichi Shinomiya,

A hydroxyapatite/type I collagen (HAp/Col) composite, aligning hydroxyapatite nanocrystals along collagen molecules, has been prepared. The biocompatibility, osteoconductive activity, and efficacy as a carrier of rhBMP-2 of this novel biomaterial implanted in the weight-bearing site have been examined. The HAp/Col implants (15 mm in diameter and 20 mm in length) with a surface cross-linked layer containing rhBMP-2 (0 or 400 microg/ml) were implanted into bone defects of tibiae in three beagle dogs and fixed according to the Ilizarov method. As a control, bone defects of 20 mm in two beagle dogs did not receive implants, and the dogs were allowed to walk using an Ilizarov extraskeletal fixator. The specimens were removed from one dog in each group after 12 weeks. Also, the Ilizarov fixators in the rhBMP-treated dogs were removed after 12 weeks, after which full weight bearing started. The specimens were further taken out after 18 and 24 weeks in the rhBMP-treated and non-rhBMP-treated dogs, and after 24 weeks in the control group. The change of bone mineral density, as well as radiological and histological findings, suggest that the implants are able to induce bone remodeling units and are a superior carrier of rhBMP-2 due to the stimulation of early callus and new bone formation.

Implantation study of a novel hydroxyapatite/collagen (HAp/col) composite into weight-bearing sites of dogs. Publishing Authors By Initials

S Itoh,M Kikuchi,K Takakuda,K Nagaoka,Y Koyama,J Tanaka,K Shinomiya,

For similar biomechanics: weight-bearing research abstracts see: biomechanics: weight-bearing research

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Implantation study of a novel hydroxyapatite/collagen (HAp/col) composite into weight-bearing sites of dogs. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomedical materials research

VOLUME: 63

Page Numbers: 507-15

Journal Abbreviation: J. Biomed. Mater. Res.

ISSN: 0021-9304

DAY: 19

MONTH: 11

YEAR: 2002

Implantation study of a novel hydroxyapatite/collagen (HAp/col) composite into weight-bearing sites of dogs. Information

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LANGUAGE: eng

NlmUniqueID: 112726

Implantation study of a novel hydroxyapatite/collagen (HAp/col) composite into weight-bearing sites of dogs. Keywords Mesh Terms:

KEYWORDS: Weight-Bearing

MESH TERMS: radiography

Chemical & Substance for Abstract: Implantation study of a novel hydroxyapatite/collagen (HAp/col) composite into weight-bearing sites of dogs. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Implantation study of a novel hydroxyapatite/collagen (HAp/col) composite into weight-bearing sites of dogs.

AFFILIATION: Department of Orthopaedic Surgery and Biomechanical Engineering, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.

Country: United States

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MEDLINETA: J Biomed Mater Res

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