Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2.

Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Research Abstract Details 

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Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Abstract Text:

C Justin Van De Wiele,Julie H Marino,Chibing Tan,Hilary A Kneale,John Weber,John N Morelli,Brenda K Davis,Ashlee A Taylor,T Kent Teague,C Justin Van de Wiele,Julie H Marino,Chibing Tan,Hilary A Kneale,John Weber,John N Morelli,Brenda K Davis,Ashlee A Taylor,T Kent Teague,

Murine thymocytes down-regulate IL-7 responsiveness following beta-selection and reacquire sensitivity after positive selection. To assess the potential consequences of IL-7 signaling during this phase of development, transgenic IL-7 receptor alpha (IL-7Ralpha) mice were evaluated for IL-7 responsiveness as gauged by STAT-5 phosphorylation. Transgenic IL-7Ralpha expression increased the percentage of thymocytes responsive to IL-7 yet resulted in a decrease in total thymic cellularity. Aberrant thymocyte development in transgenic mice was first manifested by a reduction of DN3 thymocytes that correlated with lower Bcl-2 expression. Surprisingly, transgenic restoration of Bcl-2 expression did not correct thymic hypocellularity induced by IL-7Ralpha overexpression. These findings demonstrate that failure to appropriately downregulate IL-7Ralpha expression interferes with thymocyte development past the pro-T stage resulting in significantly lower levels of mature thymocytes.

Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Publishing Authors By Initials

CJ Van De Wiele,JH Marino,C Tan,HA Kneale,J Weber,JN Morelli,BK Davis,AA Taylor,TK Teague,CJ Van de Wiele,JH Marino,C Tan,HA Kneale,J Weber,JN Morelli,BK Davis,AA Taylor,TK Teague,

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Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cellular immunology

VOLUME: 250

Page Numbers: 31-9

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ISSN: 1090-2163

DAY: 5

MONTH: 03

YEAR: 2008

Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Information

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LANGUAGE: eng

NlmUniqueID: 1246405

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Country: United States

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MEDLINETA: Cell Immunol

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