Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice.

Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. Abstract Text:

C L Wellman,A Izquierdo,J E Garrett,K P Martin,J Carroll,R Millstein,K-P Lesch,D L Murphy,A Holmes,

A lesser-expressing form of the human 5-HT transporter (5-HTT) gene has been associated with increased fear and anxiety and vulnerability to the effects of stress. These phenotypic abnormalities are linked to functional and anatomical disturbances in a neural pathway connecting the prefrontal cortex (PFC) and amygdala. Likewise, rodent and nonhuman primate studies indicate a major role for PFC and amygdala in the mediation of fear- and stress-related behaviors. We used a 5-HTT knock-out (KO) mouse to examine the effects of genetically driven loss of 5-HTT function for the following: (1) depression-related behavior in response to repeated stress, and pavlovian fear conditioning, extinction, and extinction recall; and (2) dendritic morphology and spine density of Golgi-stained pyramidal neurons in the infralimbic cortex (IL) and the basolateral amygdala (BLA). 5-HTT KO mice exhibited increased depressive-like immobility after repeated exposure to forced swim stress, compared with wild-type (WT) controls. Whereas fear conditioning and fear extinction was normal, 5-HTT KO mice exhibited a significant deficit in extinction recall. The apical dendritic branches of IL pyramidal neurons in 5-HTT KO mice were significantly increased in length relative to WT mice. Pyramidal neurons in BLA had normal dendritic morphology but significantly greater spine density in 5-HT KO mice compared with WT mice. Together, the present findings demonstrate a specific phenotypic profile of fear- and stress-related deficits in 5-HTT KO mice, accompanied by morphological abnormalities in two key neural loci. These data provide insight into the behavioral sequelae of loss of 5-HTT gene function and identify potential neural substrates underlying these phenotypes.

Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. Publishing Authors By Initials

CL Wellman,A Izquierdo,JE Garrett,KP Martin,J Carroll,R Millstein,KP Lesch,DL Murphy,A Holmes,

For similar behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research abstracts see: behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research

PUBMED ID PMID:

MEDLINE DATE:

Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 684-91

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 17

MONTH: Jan

YEAR: 2007

Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. Keywords Mesh Terms:

KEYWORDS: Stress, Psychological

MESH TERMS: metabolism

Chemical & Substance for Abstract: Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. Information

Substance Name: Serotonin Plasma Membrane Transport Prot

Registry Number: 0

Grant and Affiliation Information for Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice.

AFFILIATION: Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH067607

ACRONYM: MH

MEDLINETA: J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice Related Publications

• Alcohol dehydrogenases: gene multiplicity and differential functions of five classes of isozymes.
• An elastic rod model for anguilliform swimming.
• Assessment of a new Distance Randot stereoacuity test.
• Balancing disfigurement and fear of disease progression: Patient perceptions of HIV body fat redistribution.
• Blinded case-control study of the relationship between human coronavirus NL63 and Kawasaki syndrome.
• Changes in religiousness and spirituality attributed to HIV/AIDS: are there sex and race differences?
• Correlates of use of different types of complementary and alternative medicine by breast cancer survivors in the nurses' health study.
• Development of Synchrotron Radiation as a High-Intensity Source for X-ray Diffraction.
• Dietary fat and risk of postmenopausal breast cancer in a 20-year follow-up.
• Effect of levetiracetam on visual-spatial memory following status epilepticus.
• Electrical induction of spikes in the hippocampus impairs recognition capacity and spatial memory in rats.
• Emerging sociodemographic and lifestyle predictors of intention to use condom in human immunodeficiency virus intervention among uniformed services personnel.
• Environmental and individual predictors of error in field estimates of blood alcohol concentration: a multilevel analysis.
• Galanin as a modulator of anxiety and depression and a therapeutic target for affective disease.
• Global systems biology and personalized healthcare solutions.
• Human angiotensin-converting enzyme 2 (ACE2) is a receptor for human respiratory coronavirus NL63.
• Human coronavirus 229E can use CD209L (L-SIGN) to enter cells.
• Hydroxyproline ingestion and urinary oxalate and glycolate excretion.
• Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice.
• Molecular interactions of group 1 coronaviruses with feline APN.
• Mutational analysis of aminopeptidase N, a receptor for several group 1 coronaviruses, identifies key determinants of viral host range.
• On the dynamics of electrically-coupled neurons with inhibitory synapses.
• Ontogeny of fear-, anxiety- and depression-related behavior across adolescence in C57BL/6J mice.
• Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection.
• Rat coronavirus infection of primary rat alveolar epithelial cells.
• Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis.
• Safety, acceptability, and tolerability of 3 topical microbicides among heterosexual Kenyan men.
• Shunting and hyperpolarizing GABAergic inhibition in the high-potassium model of ictogenesis in the developing rat hippocampus.
• The ABCs of HIV prevention in men: associations with HIV risk and protective behaviors.
• Vulvar intraepithelial neoplasia III in a teenager.