Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet.

Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet. Abstract Text:

Alexandra Bernardo,Meghan McCord,Aron M Troen,John D Allison,Michael P McDonald,

Consumption of a diet that significantly elevates homocysteine (homocysteinemia) induces cell death in the CA3 hippocampal subfield in amyloid precursor protein (APP) over-expressing transgenic mice but not in wild-type controls. We assessed behavioral and other neuropathological effects of a homocysteinemia-inducing diet in aged APP-overexpressing mice. Starting at 16-18 months of age, mice were fed either a treatment diet lacking folate, choline, and methionine, and supplemented with homocysteine, or a control diet containing normal amounts of folate, choline and methionine but no homocysteine. After 5 months on the experimental diets, performance on a delayed non-matching-to-position working-memory task was unimpaired. In contrast, spatial reference memory in the water maze was impaired in transgenic mice on the treatment diet. Transgenic mice had higher homocysteine levels than wild-type mice even when fed the control diet, suggesting an effect of genotype on homocysteine metabolism. Methyl-donor deficiency did not alter amyloid deposition in the transgenic mice. These results suggest that disrupted homocysteine metabolism may induce Abeta-associated memory impairments and neurodegeneration in APP overexpressing mice.

Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet. Publishing Authors By Initials

A Bernardo,M McCord,AM Troen,JD Allison,MP McDonald,

For similar psychological phenomena and processes: mental processes: perception: space perception research abstracts see: psychological phenomena and processes: mental processes: perception: space perception research

PUBMED ID PMID:

MEDLINE DATE:

Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neurobiology of aging

VOLUME: 28

Page Numbers: 1195-205

Journal Abbreviation: Neurobiol. Aging

ISSN: 1558-1497

DAY: 11

MONTH: 07

YEAR: 2006

Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8100437

Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet. Keywords Mesh Terms:

KEYWORDS: Space Perception

MESH TERMS: physiology

Chemical & Substance for Abstract: Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet. Information

Substance Name: Homocystine

Registry Number: 462-10-2

Grant and Affiliation Information for Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet.

AFFILIATION: Department of Pharmacology, Vanderbilt University, Nashville, TN 37232-0325, United States.

Country: United States

AGENCY: United States NICHD

GRANT: HD015052

ACRONYM: HD

MEDLINETA: Neurobiol Aging

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet Related Publications

• A computerized decision support system improves the accuracy of temperature capture from nursing personnel at the bedside.
• A novel subpopulation of 5-HT type 3A receptor subunit immunoreactive interneurons in the rat basolateral amygdala.
• A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease.
• Acute interhemispheric subdural haematoma.
• Atlanto-occipital and atlanto-axial instability in children with Down syndrome.
• Automated mapping of local radiology terms to LOINC.
• Ayurveda and acupuncture in heroin detoxification in Sri Lanka.
• Chronic kidney disease in long-term survivors of hematopoietic cell transplant.
• Computerized reminders to improve isolation rates of patients with drug-resistant infections: design and preliminary results.
• Conducting Translation Research in the Home Care Setting: Lessons from a Just-in-Time Reminder Study.
• Efficiency, comprehensiveness and cost-effectiveness when comparing dictation and electronic templates for operative reports.
• Es07 microarray gene expression analysis of human adrenocortical tumours.
• Examination of the mouth.
• Extensible Stylesheet Language Formatting Objects (XSL-FO): a tool to transform patient data into attractive clinical reports.
• Fischer carbene catalysis of alkynol cycloisomerization: application to the synthesis of the altromycin B disaccharide.
• Functional significance of Asn-linked glycosylation of proteinase 3 for enzymatic activity, processing, targeting, and recognition by anti-neutrophil cytoplasmic antibodies.
• Group a streptococcus osteomyelitis and septic arthritis following varicella: Case report and review of the literature.
• Human serum amyloid A3 peptide enhances intestinal MUC3 expression and inhibits EPEC adherence.
• Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.
• Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet.
• In support of emergency department health information technology.
• Physiochemical properties of oviductal fluid from rabbits exposed to heat stress.
• Rapid vascular regrowth in tumors after reversal of VEGF inhibition.
• S641 contributes HERG k+ channel inactivation.
• Sarcomere length dependence of rat skinned cardiac myocyte mechanical properties: dependence on myosin heavy chain.
• Sexual behavior of farm animals.
• Spatial and nonspatial escape strategies in the Barnes maze.
• Survivin promoter-based conditionally replicative adenoviruses target cholangiocarcinoma.
• Targeted adenoviral gene transfer to the kidney.
• Tissue-sparing effect of x-ray microplanar beams particularly in the CNS: is a bystander effect involved?