Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.

Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Research Abstract Details 

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Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Abstract Text:

R S Reiserer,F E Harrison,D C Syverud,M P McDonald,

Mice co-expressing the Swedish amyloid precursor protein mutation (APP(Swe)) and exon 9 deletion (DeltaE9) of the PSEN1 gene begin to develop amyloid plaques at 6-7 months of age. We demonstrate here a spatial learning deficit in 7-month-old APP(Swe) + PSEN1DeltaE9 bigenic mice using an adaptation of the Barnes maze. Mice were first trained on a cued target followed by a hidden-target condition. Although bigenic mice quickly learned the cued-target version of the task, they were significantly impaired when switched to the hidden-target version. In contrast, a separate group of double-transgenic mice trained first on the spatial hidden-target version of the task were unimpaired relative to wild-type controls. We propose that processes such as general rule learning, context learning and exploratory habituation exert a greater influence when the testing environment is novel and overshadow the spatial memory deficit in naive bigenic mice. However, when cued-target training is conducted first, these processes habituate and the spatial learning deficit is unmasked. Seven-month-old APP(Swe) + PSEN1DeltaE9 mice were unimpaired on tests of memory that did not involve learning the rules governing spatial associations.

Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Publishing Authors By Initials

RS Reiserer,FE Harrison,DC Syverud,MP McDonald,

For similar behavior and behavior mechanisms: behavior: spatial behavior research abstracts see: behavior and behavior mechanisms: behavior: spatial behavior research

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Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genes, brain, and behavior

VOLUME: 6

Page Numbers: 54-65

Journal Abbreviation: Genes Brain Behav.

ISSN: 1601-1848

DAY: 3

MONTH: Feb

YEAR: 2007

Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Information

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LANGUAGE: eng

NlmUniqueID: 101129617

Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Spatial Behavior

MESH TERMS: physiology

Chemical & Substance for Abstract: Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Information

Substance Name: Presenilin-1

Registry Number: 0

Grant and Affiliation Information for Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.

AFFILIATION: Department of Pharmacology, Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232-0325, USA.

Country: England

AGENCY: United States NICHD

GRANT: HD015052

ACRONYM: HD

MEDLINETA: Genes Brain Behav

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