Impaired endothelial function in hypertensive elderly patients evaluated by high resolution ultrasonography.

Impaired endothelial function in hypertensive elderly patients evaluated by high resolution ultrasonography. Research Abstract Details 

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Impaired endothelial function in hypertensive elderly patients evaluated by high resolution ultrasonography. Abstract Text:

Y Kimura,M Matsumoto,Y B Den,K Iwai,J Munehira,H Hattori,T Hoshino,K Yamada,K Kawanishi,H Tsuchiya,

BACKGROUND: Multiple investigations both in experimental models and in middle-aged patients with essential hypertension have demonstrated impaired endothelium-dependent vasodilation. OBJECTIVE: To determine whether hypertension exerts an additional negative effect on endothelial function of large arteries in hypertensive elderly patients who may already be affected by endothelial dysfunction due to aging. PATIENTS AND METHODS: Thirteen elderly patients with hypertension (69 9 years of age [mean SD]) were compared with 13 matched healthy elderly subjects (72 6 years of age). High resolution vascular ultrasound was used to measure brachial artery responses to reactive hyperemia (with increased flow causing endothelium-dependent dilation) and to sublingual nitroglycerine (causing endothelium-independent dilation). RESULTS: Flow-mediated diameter (FMD) was significantly impaired in the hypertensive elderly group (6.7 3.3% versus 13.3 3.8% in the control group, P<0.05). No significant difference could be found in nitroglycerine-induced dilation between the elderly control group (12.1 4.9%) and the hypertensive elderly (10.2 6.8%). On simple linear analysis, FMD was inversely correlated with age (r=-0.60, P=0. 03) in the healthy elderly group. FMD in the hypertensive elderly was inversely related to age (r=-0.41, P=0.04) and mean blood pressure (r=-0.67, P=0.01). CONCLUSIONS: This study showed decreased FMD with aging even in the healthy elderly, with a further decline in hypertensive elderly compared with healthy elderly subjects. This impairment of FMD in the hypertensive elderly group was related to age and mean blood pressure, indicating that aging and hypertension may impair endothelial function in the brachial artery of elderly patients with hypertension.

Impaired endothelial function in hypertensive elderly patients evaluated by high resolution ultrasonography. Publishing Authors By Initials

Y Kimura,M Matsumoto,YB Den,K Iwai,J Munehira,H Hattori,T Hoshino,K Yamada,K Kawanishi,H Tsuchiya,

For similar diagnosis: diagnostic techniques and procedures: diagnostic imaging: ultrasonography research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic imaging: ultrasonography research

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Impaired endothelial function in hypertensive elderly patients evaluated by high resolution ultrasonography. Journal Published:

PUBLICATION TYPE: Review

Journal: The Canadian journal of cardiology

VOLUME: 15

Page Numbers: 563-8

Journal Abbreviation:

ISSN: 0828-282X

DAY: 9

MONTH: May

YEAR: 1999

Impaired endothelial function in hypertensive elderly patients evaluated by high resolution ultrasonography. Information

Number of References: 36

LANGUAGE: eng

NlmUniqueID: 8510280

Impaired endothelial function in hypertensive elderly patients evaluated by high resolution ultrasonography. Keywords Mesh Terms:

KEYWORDS: Ultrasonography

MESH TERMS: methods

Chemical & Substance for Abstract: Impaired endothelial function in hypertensive elderly patients evaluated by high resolution ultrasonography. Information

Substance Name: Cholesterol

Registry Number: 57-88-5

Grant and Affiliation Information for Impaired endothelial function in hypertensive elderly patients evaluated by high resolution ultrasonography.

AFFILIATION: Kanazawa Medical University, Uchinada, Japan.

Country: CANADA

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MEDLINETA: Can J Cardiol

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