Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma.

Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma. Abstract Text:

Tomoyoshi Ohno,Noboru Hirashima,Etsuro Orito,Izumi Hasegawa,Kei Fujiwara,Kiyoaki Itoh,Atsushi Ozasa,Noboru Shinkai,Yasuhito Tanaka,Takanobu Kato,Ryuzo Ueda,Kenji Sakakibara,

Aim: Peptide-based therapeutic vaccines are being developed. The aim of this study was to determine the feasibility of immunotherapy to hepatitis C virus (HCV)-positive hepatocellular carcinoma (HCC) by assessing the inductivity of peptide-specific cytotoxic T lymphocyte (CTL) by dendritic cells. Methods: The inductivity of CTL was characterized in six patients with HCV-positive HCC, and compared to seven healthy volunteers and six patients with chronic HCV hepatitis (control). Results: Peptide-specific CTL was comparably induced in controls, but not induced in any patients with HCC. To characterize this, the cytokine profile and the expression of surface molecules interacting between dendritic and T cells were evaluated. Among the cytokines, production of interferon (IFN)-gamma was found to be impaired and closely related to the results of CTL assays, while the expression of surface molecules showed no significant changes. Conclusions: In HCV-positive HCC patients, CTL inductivity by dendritic cells is impaired. This may be related to the impaired production of IFN-gamma.

Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma. Publishing Authors By Initials

T Ohno,N Hirashima,E Orito,I Hasegawa,K Fujiwara,K Itoh,A Ozasa,N Shinkai,Y Tanaka,T Kato,R Ueda,K Sakakibara,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 37

Page Numbers: 276-85

Journal Abbreviation: Hepatol. Res.

ISSN: 1386-6346

DAY: 2

MONTH: Apr

YEAR: 2007

Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9711801

Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma.

AFFILIATION: Department of Gastroenterology, Social Insurance Chukyo Hospital, Nagoya, Japan.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Hepatol Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma Related Publications

• (Lysyl-Glycyl-Glycyl)5 and (Lysyl-Glycyl-Glycyl)10 as models of histone. Interaction with DNA and acetylation by calf thymus enzyme.
• 5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-alpha]pyridine-8-carboxamide (CJ-033,466), a novel and selective 5-hydroxytryptamine4 receptor partial agonist: pharmacological profile in vitro and gastroprokinetic effect in consc
• A new fluorogenic substrate method for the estimation of kallikrein in urine.
• Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta.
• Coronary to bronchial artery anastomosis in patients with noncyanotic cardiopulmonary disease: report of seven cases.
• Dissociation of a complex of F-actin and H-meromyosin by addition of adenosine triphosphate.
• Effect of intestinal microflora on the production of interleukin 10 and prostaglandin e(2) in serum and kupffer cells from germfree and conventional mice.
• Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma.
• Inhibition of fructose-6-phosphate,2-kinase by N-bromoacetylethanolamine phosphate in vitro and in vivo.
• Isolation of an inhibitor of beta-glucuronidase from human saliva.
• KINETIC STUDIES OF ACTIN POLYMERIZATION AND EFFECTS OF MYOSIN A AND H-MEROMYOSIN ON THE POLYMERIZATION.
• New fluorogenic peptide substrates for plasmin.
• PSSMTS: position specific scoring matrices on tree structures.
• Pneumopericardium 3 years after lung cancer surgery.
• Preoperative CYFRA 21-1 levels as a prognostic factor in c-stage I non-small cell lung cancer.
• Prone positioning improves distribution of pulmonary perfusion: noninvasive magnetic resonance imaging study in healthy humans.
• Rate determining step of the coupled reaction system composed of H-meromyosin-adenosinetriphosphatase and creatine kinase.
• Regulation of cytokinin biosynthesis, compartmentalization and translocation.
• Structural insight into the reaction mechanism and evolution of cytokinin biosynthesis.
• The relationship between adaptive cytoprotection and prostaglandin contents in the rat stomachs after oral administration of 0.35 N HCl.
• [A case report of emergency surgical resection of left ventricular aneurysm associated with mobile pedunculated thrombi (author's transl)]
• [A successful use of VAS for bridge to heart transplantation after oversea transportation in a 18-year-old patient with dilated cardiomyopathy]
• [Double-outlet right ventricle--surgical treatment and clinical evaluation of 38 autopsy cases]
• [Evaluation of left ventricular function and coronary sinus blood flow during exercise after aortocoronary bypass surgery--influence of complete revascularization of the left coronary artery]
• [Experimental study on reversibility of acute myocardial infarction]
• [Heart surgery and hyperbaric oxygenation]
• [Hemodilution in practice of cardiopulmonary bypass for infants open heart surgery (author's transl)]
• [Hemodynamic and electrocardigraphic characteristics, and their surgical implications in patients with postinfarction septal perforation (author's transl)]
• [The influence of A-V synchrony and changes in heart rate on rate responsive pacing]
• [Therapeutical problems of aortic regurgitation associated with Behçet disease]