Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP).

Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP). Research Abstract Details 

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Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP). Abstract Text:

To clarify the involvement of membrane-type matrix metalloproteinase 1 (MT1-MMP) in lung organogenesis, we studied the lung morphology of 13-day-old MT1-MMP null mice. The lung architecture in MT1-MMP null mice was abnormal, and the airspace compartments were characterized by smooth walls and larger size. Most of the compartment wall consisted of one or two layers of cells and interstitial connective tissue that was thicker than that of normal alveoli. The wall frequently had capillaries on both sides of the interstitial connective tissue. These findings indicate that the lung in MT1-MMP null mice at 13 days of age is comparable to that of neonatal mice, i.e., it represents the stage before alveolization, suggesting that the generation of a large respiratory surface - the final process of lung development - is impaired in MT1-MMP null mice. Moreover, a zymography assay revealed decreased activity of matrix metalloproteinase 2 (MMP-2) in MT1-MMP null mice, suggesting that activation of pro-MMP-2 by MT1-MMP is critical in this process.

Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP). Publishing Authors By Initials

For similar respiratory system: lung: pulmonary alveoli research abstracts see: respiratory system: lung: pulmonary alveoli research

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Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Medical molecular morphology

VOLUME: 38

Page Numbers: 43-6

Journal Abbreviation: Med Mol Morphol

ISSN: 1860-1480

DAY: 17

MONTH: Mar

YEAR: 2005

Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP). Information

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LANGUAGE: eng

NlmUniqueID: 101239023

Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP). Keywords Mesh Terms:

KEYWORDS: Pulmonary Alveoli

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP). Information

Substance Name: Matrix Metalloproteinase 14

Registry Number: EC 3.4.24.80

Grant and Affiliation Information for Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP).

AFFILIATION: Department of Oral Anatomy, Health Sciences University of Hokkaido School of Dentistry, Ishikari-Tobetsu, Japan. irie@hoku-iryo-u.ac.jp

Country: Japan

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MEDLINETA: Med Mol Morphol

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