Impact of valvular thickness on stroke recurrence in medically treated patients with stroke.

Impact of valvular thickness on stroke recurrence in medically treated patients with stroke. Research Abstract Details 

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Impact of valvular thickness on stroke recurrence in medically treated patients with stroke. Abstract Text:

K Okajima,Y Abe,K Suzuki,M J Salameh,M R Di Tullio,Z Jin,R L Sacco,J P Mohr,S Homma, ,K Okajima,Y Abe,K Suzuki,M J Salameh,M R Di Tullio,Z Jin,R L Sacco,J P Mohr,S Homma, ,

BACKGROUND: It remains controversial whether left-sided valvular thickening (VaT) is a risk factor for ischemic stroke. Little is known about the relationship between VaT and the recurrent adverse event rate in medically treated patients with stroke. METHODS: We examined the outcomes of 627 noncardioembolic stroke patients who were double-blindly assigned to either warfarin or aspirin therapy and assessed VaT using transesophageal echocardiography. Endpoints were recurrent ischemic stroke or death from any cause. The Cox proportional hazards model was used to adjust for covariates. RESULTS: VaT was present in 57.3% of the patients (359/627), 34.6% (271/627) involving the aortic valve and 46.4% (291/627) involving the mitral valve. There was no difference in the time to primary endpoints between those with and without VaT of the aortic valve (p = 0.49; hazard ratio, HR: 1.17; 95% CI: 0.74-1.85; 2-year event rates: 18.9 vs. 13.2%) or mitral valve (p = 0.66; HR: 0.91; 95% CI: 0.60-1.38; 2-year event rates: 16.9 vs. 14.7%). Among the patients with VaT, there was no significant difference in the time to primary endpoints between those treated with warfarin and those with aspirin (p = 0.13, HR: 0.65, 95% CI: 0.37-1.14, 2-year event rates: 15.2 vs. 22.7% for the aortic valve; p = 0.22, HR: 0.70, 95% CI: 0.40-1.23, 2-year event rates: 14.2 vs. 19.6% for the mitral valve). CONCLUSIONS: VaT does not appear to increase recurrent adverse event rates in medically treated patients with ischemic stroke, regardless of warfarin or aspirin therapy.

Impact of valvular thickness on stroke recurrence in medically treated patients with stroke. Publishing Authors By Initials

K Okajima,Y Abe,K Suzuki,MJ Salameh,MR Di Tullio,Z Jin,RL Sacco,JP Mohr,S Homma, ,K Okajima,Y Abe,K Suzuki,MJ Salameh,MR Di Tullio,Z Jin,RL Sacco,JP Mohr,S Homma, ,

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Impact of valvular thickness on stroke recurrence in medically treated patients with stroke. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cerebrovascular diseases (Basel, Switzerland)

VOLUME: 24

Page Numbers: 375-80

Journal Abbreviation: Cerebrovasc. Dis.

ISSN: 1015-9770

DAY: 5

MONTH: 09

YEAR: 2007

Impact of valvular thickness on stroke recurrence in medically treated patients with stroke. Information

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LANGUAGE: eng

NlmUniqueID: 9100851

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AFFILIATION: Department of Medicine, Columbia University, New York, NY 10032, USA. OkajimaKazue@aol.com

Country: Switzerland

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MEDLINETA: Cerebrovasc Dis

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