Impact of treatment of gastroesophageal reflux on obstructive sleep apnea-hypopnea syndrome.

Impact of treatment of gastroesophageal reflux on obstructive sleep apnea-hypopnea syndrome. Research Abstract Details 

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Impact of treatment of gastroesophageal reflux on obstructive sleep apnea-hypopnea syndrome. Abstract Text:

Michael Friedman,Berk Gurpinar,Hsin-Ching Lin,Paul Schalch,Ninos J Joseph,Michael Friedman,Berk Gurpinar,Hsin-Ching Lin,Paul Schalch,Ninos J Joseph,

OBJECTIVES: We test the hypothesis that treatment of gastroesophageal reflux disease (GERD) can improve obstructive sleep apnea-hypopnea syndrome (OSAHS). METHODS: One hundred forty-six patients with OSAHS underwent a complete history-taking, physical examination, and laboratory testing, including questions related to GERD symptoms. Full-night attended polysomnography, 24-hour wireless pH study at the upper esophagus, snoring level evaluation, Epworth Sleepiness Scale, and quality-of-life surveys were completed for each patient. Patients who tested positive for GERD were treated with esomeprazole magnesium 40 mg once daily for 2 to 12 months. The 24-hour pH study was repeated, and those patients with elimination of GERD were reevaluated by polysomnography, snoring level evaluation, Epworth Sleepiness Scale, quality-of-life surveys, and subjective data collection. RESULTS: Forty-one patients completed single-dose treatment with esomeprazole, but the repeat 24-hour pH study showed that 9 patients had persistent GERD. In the 29 patients who completed phase 2 with normal pH study findings, the snoring level decreased from 9.7 +/- 0.5 to 7.9 +/- 1.3 (p < .0001), the Epworth Sleepiness Scale score decreased from 14.2 +/- 2.5 to 11.1 +/- 2.4 (p < .0001), the apnea-hypopnea index decreased from 37.9 +/- 19.1 to 28.8 +/- 11.5 (p = .006), and the minimum saturation of oxygen increased from 84.1% +/- 7.8% to 86.9% +/- 5.0% (p = .055). CONCLUSIONS: Treatment of GERD had a significant impact on the reduction of the apnea-hypopnea index, snoring, and daytime sleepiness. Elimination of GERD should be part of a comprehensive treatment plan for patients with OSAHS.

Impact of treatment of gastroesophageal reflux on obstructive sleep apnea-hypopnea syndrome. Publishing Authors By Initials

M Friedman,B Gurpinar,HC Lin,P Schalch,NJ Joseph,M Friedman,B Gurpinar,HC Lin,P Schalch,NJ Joseph,

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Impact of treatment of gastroesophageal reflux on obstructive sleep apnea-hypopnea syndrome. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Annals of otology, rhinology, and laryngology

VOLUME: 116

Page Numbers: 805-11

Journal Abbreviation: Ann. Otol. Rhinol. Laryngol.

ISSN: 0003-4894

DAY: 13

MONTH: Nov

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 407300

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AFFILIATION: Department of Otolaryngology and Bronchoesophagology, Rush University Medical Center, Chicago, IL, USA.

Country: United States

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MEDLINETA: Ann Otol Rhinol Laryngol

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