Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model.

Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model. Research Abstract Details 

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Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model. Abstract Text:

Louise D Christensen,Claus Moser, Jensen,Thomas B Rasmussen,Lars Christophersen,Staffan Kjelleberg,Naresh Kumar,Niels ,Michael Givskov,Thomas Bjarnsholt,

Pseudomonas aeruginosa is an opportunistic human pathogen that causes chronic biofilm-based infections in host organisms. P. aeruginosa employs quorum sensing (QS) to control expression of its virulence, and to establish and maintain chronic infections. Under such conditions, the biofilm mode of growth contributes significantly to P. aeruginosa tolerance to the action of the innate and adaptive defence system and numerous antibiotics. In the present study, an in vivo foreign-body infection model was established in the peritoneal cavity of mice. Experimental data showed that QS-deficient P. aeruginosa are cleared more rapidly from silicone implants as compared to their wild-type counterparts. Concurrently, treatment with the QS inhibitor furanone C-30 of mice harbouring implants colonized with the wild-type P. aeruginosa resulted in a significantly faster clearing of the implants as compared to the placebo-treated group. These results were obtained with both an inbred (BALB/c) and an outbred (NMRI) mouse strain. The present results support a model by which functional QS systems play a pivotal role in the ability of bacteria to resist clearing by the innate immune system and strongly suggest that the efficiency of the mouse innate defence against biofilm-forming P. aeruginosa is improved when the bacteria are treated with QS drugs that induce QS deficiency.

Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model. Publishing Authors By Initials

LD Christensen,C Moser, Jensen,TB Rasmussen,L Christophersen,S Kjelleberg,N Kumar,N ,M Givskov,T Bjarnsholt,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: quorum sensing research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: quorum sensing research

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Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Microbiology (Reading, England)

VOLUME: 153

Page Numbers: 2312-20

Journal Abbreviation: Microbiology (Reading, Engl.)

ISSN: 1350-0872

DAY: 27

MONTH: Jul

YEAR: 2007

Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model. Information

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LANGUAGE: eng

NlmUniqueID: 9430468

Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model. Keywords Mesh Terms:

KEYWORDS: Quorum Sensing

MESH TERMS: drug effects

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Grant and Affiliation Information for Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model.

AFFILIATION: Bioscience and Technology, BioCentrum, Technical University of Denmark, DK-2800 Lyngby, Denmark.

Country: England

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MEDLINETA: Microbiology

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