Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal anastomosis for rectal cancers.

Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal anastomosis for rectal cancers. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal anastomosis for rectal cancers. Abstract Text:

Imran Hassan,David W Larson,Bruce G Wolff,Robert R Cima,Heidi K Chua,Dieter Hahnloser,Megan M O'Byrne,Dirk R Larson,John H Pemberton,

PURPOSE: This study was designed to assess the impact of pelvic radiotherapy on the incidence of complications and colostomy-free survival of patients after a coloanal anastomosis for rectal cancer. METHODS: A total of 192 patients underwent a coloanal anastomosis between 1982 and 2001: 87 patients did not receive pelvic radiotherapy; 105 patients received pelvic radiotherapy (39 preoperative and 66 postoperative). Early and late complications requiring surgical intervention and the colostomy-free survival rate were assessed by retrospective review of patient records. RESULTS: After a median follow-up of 62 months, 151 patients were alive. The most frequent complication was development of an anastomotic stricture (5-year rate of a stricture, 16 percent; 95 percent confidence interval, 10-21). Patients receiving pelvic radiotherapy had a higher rate of complications other than anastomotic strictures, including fecal incontinence, fistulas, abscesses, and bowel obstructions compared with patients not receiving pelvic radiotherapy (5-year rate: 20 percent (95 percent confidence interval, 10-29) vs. 5 percent (95 percent confidence interval, 0-10); P = 0.001). Patients receiving pelvic radiotherapy had a lower colostomy-free survival than did patients not receiving pelvic radiotherapy (5-year colostomy-free rate: 72 percent (95 percent confidence interval, 62-84) vs. 92 percent (95 percent confidence interval, 86-98); P < 0.001). There was no significant difference in the colostomy-free survival of patients receiving preoperative and postoperative pelvic radiotherapy. CONCLUSIONS: After coloanal anastomosis, a significant number of patients will have complications requiring surgical intervention, and some will require a permanent colostomy. Pelvic radiotherapy, whether it is administered preoperatively or postoperatively, significantly increases the need for a permanent colostomy.

Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal anastomosis for rectal cancers. Publishing Authors By Initials

I Hassan,DW Larson,BG Wolff,RR Cima,HK Chua,D Hahnloser,MM O'Byrne,DR Larson,JH Pemberton,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal anastomosis for rectal cancers. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Diseases of the colon and rectum

VOLUME: 51

Page Numbers: 32-7

Journal Abbreviation: Dis. Colon Rectum

ISSN: 0012-3706

DAY: 21

MONTH: 11

YEAR: 2007

Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal anastomosis for rectal cancers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372764

Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal anastomosis for rectal cancers. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal anastomosis for rectal cancers. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal anastomosis for rectal cancers.

AFFILIATION: Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, USA, larson.david2@mayo.edu.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Dis Colon Rectum

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal anastomosis for rectal cancers Related Publications

• A sociomedical study of 200 hospital medical patients.
• Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts.
• Commentary: On the article by Lester Breslow on the origins and development of the IEA.
• Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury.
• Effect of infliximab on short-term complications in patients undergoing operation for chronic ulcerative colitis.
• Hp18 the good, the fat and the ugly: metabolic hormones and the heart.
• Hypertension, cardiotrophin-1 and gp130: three points to heart failure?
• Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.
• Illness in general practice.
• Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal anastomosis for rectal cancers.
• Internet use by patients in an inflammatory bowel disease specialty clinic.
• Landscape features affect gene flow of Scottish Highland red deer (Cervus elaphus).
• Leptin-induced cardiac hypertrophy: RhoAing a lipid raft down a protective p38 MAPK signalling stream?
• Model aluminum-poly(p-phenylenevinylene) interfaces studied by surface raman spectroscopy.
• Mutational analysis of H3 and H4 N termini reveals distinct roles in nuclear import.
• Möbius aromaticity in [12]annulene: cis-trans isomerization via twist-coupled bond shifting.
• Observations on diseases among British prisoners of war in Japanese hands in the Far East, 1942-1945.
• Organic dust exposure increases mast cell tryptase in bronchoalveolar lavage fluid and airway epithelium of heaves horses.
• Phosphorylation by casein kinase 2 regulates Nap1 localization and function.
• Radiology, radiation and risk.
• SEMANTICS AND COMMUNICATION.
• THE EFFECT OF OPERATIVE ALTERATIONS IN THE HEIGHT OF THE EXTERNAL RECTUS INSERTION.
• The cloning and characterization of a second alpha-amylase of A. hydrophila JMP636.
• The expression of intelectin in sheep goblet cells and upregulation by interleukin-4.
• Treatment acceptability among mexican american parents.
• Treatment of arthritis.
• Treatment of megacolon and megarectum.
• Trichinella spiralis induces de novo expression of group IVC phospholipase A(2) in the intestinal epithelium.
• Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta.
• Wild pedigrees: the way forward.