Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus.

Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus. Research Abstract Details 

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Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus. Abstract Text:

Heiko T Jansen,John D Kirby,Paul S Cooke,Niromi Arambepola,Gary A Iwamoto,

Thyroid hormones play an important role in brain development. In the present study, we examined the influence of transient postnatal hypothyroidism on reproductive neuroendocrine and behavioral outcomes in the male Syrian (golden) hamster. Hamster pups were rendered hypothyroid following exposure to the goitrogen, 6-n-propyl-2-thiouracil (PTU), between postnatal (PN) day 0 (birth) and PN25 (weaning). By 15 days after cessation of PTU, exposure (PN40) serum thyroxine levels had returned to control levels. The testes of treated males were approximately 30% heavier than controls and daily sperm production was increased by 73%. Immunocytochemistry for GnRH revealed that the total number of GnRH neurons did not vary between groups; however, a shift in the distribution of GnRH neurons was observed in treated males such that more GnRH immunoreactive neurons were found in the caudal portion of their normal distribution. The shift in GnRH distribution was associated with a significant reduction (40-50%) in pituitary gonadotropin secretion. Behaviorally, treated males took significantly longer to investigate the anogenital region and then mount a receptive female. A corresponding reduction in the total number of anogenital investigations and mounts was observed. This difference between treated males and controls was reduced, but not eliminated, over successive trials and by the third trial the number of intromission was similar between treated and control males. We conclude that the full complement of adult reproductive functions observed in the male golden hamster requires thyroid hormones during the early postnatal period. The severity of the effects induced by early hypothyroidism in this species varies from transient to permanent, depending on the endpoint.

Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus. Publishing Authors By Initials

HT Jansen,JD Kirby,PS Cooke,N Arambepola,GA Iwamoto,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyroxine research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyroxine research

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Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Physiology & behavior

VOLUME: 90

Page Numbers: 771-81

Journal Abbreviation: Physiol. Behav.

ISSN: 0031-9384

DAY: 13

MONTH: 01

YEAR: 2007

Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 151504

Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus. Keywords Mesh Terms:

KEYWORDS: Thyroxine

MESH TERMS: blood

Chemical & Substance for Abstract: Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus. Information

Substance Name: Thyroxine

Registry Number: 7488-70-2

Grant and Affiliation Information for Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus.

AFFILIATION: Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, 205 Wegner Hall Pullman, WA 99164-6520, United States. heiko@vetmed.wsu.edu

Country: United States

AGENCY: United States NICHD

GRANT: HD07841

ACRONYM: HD

MEDLINETA: Physiol Behav

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