Impact of microgel morphology on functionalized microgel-drug interactions.

Impact of microgel morphology on functionalized microgel-drug interactions. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Impact of microgel morphology on functionalized microgel-drug interactions. Abstract Text:

Todd Hoare,Robert Pelton,Todd Hoare,Robert Pelton,

The interactions of a range of water-soluble drugs of different charges and hydrophobicities with carboxylic acid-functionalized poly(N-isopropylacrylamide)-based microgels containing different functional group distributions are investigated to determine the impact of drug properties and microgel morphologies on drug uptake and release. The radial distribution of carboxylic acid functional groups in the microgel and the hydrophobicities of the cationic drugs both strongly affect drug partitioning between the solution and microgel phases. Microgels with surface-localized functional group distributions bind less cationic drug than bulk-functionalized microgels, likely due to the formation of a locally collapsed "skin layer" at the acid-base drug binding sites at the microgel surface. In this way, cationic drugs induce a local phase transition that can be used to regulate small molecule diffusion in and out of the gel. As the drug hydrophobicity is increased, the skin layer becomes more condensed and less drug uptake is achieved. In the case of anionic or neutral drugs, high drug uptakes are achieved independent of the functional group distribution within the microgel. High drug uptake is also observed when nonfunctionalized poly(N-isopropylacrylamide) microgels are used as the uptake matrix, suggesting the importance of hydrophobic partitioning in regulating drug-microgel interactions.

Impact of microgel morphology on functionalized microgel-drug interactions. Publishing Authors By Initials

T Hoare,R Pelton,T Hoare,R Pelton,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Impact of microgel morphology on functionalized microgel-drug interactions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Langmuir : the ACS journal of surfaces and colloid

VOLUME: 24

Page Numbers: 1005-12

Journal Abbreviation:

ISSN: 0743-7463

DAY: 8

MONTH: 01

YEAR: 2008

Impact of microgel morphology on functionalized microgel-drug interactions. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9882736

Impact of microgel morphology on functionalized microgel-drug interactions. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Impact of microgel morphology on functionalized microgel-drug interactions. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Impact of microgel morphology on functionalized microgel-drug interactions.

AFFILIATION: Department of Chemical Engineering McMaster University 1280 Main St. W., Hamilton, Ontario, Canada L8S 4L7.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Langmuir

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Impact of microgel morphology on functionalized microgel-drug interactions Related Publications

• 1. Introduction.
• A comparative evaluation of three discriminant scales for endogenous depression.
• Charge-switching, amphoteric glucose-responsive microgels with physiological swelling activity.
• Current effort to control dental caries.
• Dental caries data obtained by simplified method and correlated with fluorine data in four Wyoming cities.
• Forms of atypical depression and their response to antidepressant drugs.
• Functionalized microgel swelling: comparing theory and experiment.
• Gearing Dental Public Health to Meet Wartime Conditions.
• Impact of microgel morphology on functionalized microgel-drug interactions.
• Microgel-based inks for paper-supported biosensing applications.
• Our public image.
• Photoflocculation of TiO2 Microgel Mixed Suspensions.
• Prospects for prevention of otitis media.
• Recent advances in otitis media. Animal models of otitis media.
• Replacement pneumococcal disease in perspective.
• Role of complement in defense of the middle ear revealed by restoring the virulence of nontypeable Haemophilus influenzae siaB mutants.
• Routine restaurant inspections and education of food handlers: recommendations based on critical appraisal of the literature and survey of Canadian jurisdictions on restaurant inspections and education of food handlers.
• The effect of zinc chloride and potassium ferrocyanide as a caries prophylaxis.
• The evaluation of the effectiveness of routine restaurant inspections and education of food handlers: restaurant inspection survey.