Impact of E2F-1 Expression on Clinical Outcome of Gastric Adenocarcinoma Patients with Adjuvant Chemoradiation Therapy.

Impact of E2F-1 Expression on Clinical Outcome of Gastric Adenocarcinoma Patients with Adjuvant Chemoradiation Therapy. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Impact of E2F-1 Expression on Clinical Outcome of Gastric Adenocarcinoma Patients with Adjuvant Chemoradiation Therapy. Abstract Text:

Jeeyun Lee,Cheol Keun Park,Joon Oh Park,Taekyu Lim,Young Suk Park,Ho Yeong Lim,Inkyoung Lee,Tae Sung Sohn,Jae Hyung Noh,Jin Seok Heo,Sung Kim,Do Hoon Lim,Kyoung-Mee Kim,Won Ki Kang,Jeeyun Lee,Cheol Keun Park,Joon Oh Park,Taekyu Lim,Young Suk Park,Ho Yeong Lim,Inkyoung Lee,Tae Sung Sohn,Jae Hyung Noh,Jin Seok Heo,Sung Kim,Do Hoon Lim,Kyoung-Mee Kim,Won Ki Kang,Jeeyun Lee,Cheol Keun Park,Joon Oh Park,Taekyu Lim,Young Suk Park,Ho Yeong Lim,Inkyoung Lee,Tae Sung Sohn,Jae Hyung Noh,Jin Seok Heo,Sung Kim,Do Hoon Lim,Kyoung-Mee Kim,Won Ki Kang,

PURPOSE: There are no reliable prognostic markers that identify gastric cancer patients who may benefit from adjuvant chemoradiation therapy. E2F-1 was shown to be associated with radiosensitivity and chemosensitivity in certain tumor types. Therefore, we analyzed expression and prognostic significance of E2F-1 along with thymidylate synthase (TS) in R(0)-resected gastric adenocarcinoma patients, who underwent adjuvant chemoradiation therapy with 5-fluorouracil (5-FU) and leucovorin. EXPERIMENTAL DESIGN: The chemosensitivity to 5-FU and radiosensitivity were tested in three E2F-1-overexpressed gastric cancer cell lines in vitro. The expressions of TS and E2F-1 were analyzed in 467 R(0)-resected primary gastric cancer patients, who received adjuvant chemoradiation therapy with 5-FU and leucovorin using tissue microarray. RESULTS: The E2F-1 immunopositivity rate was 22.2% (103 of 465 samples) with a cutoff value of 5% immunoreactivity, whereas the TS-positive expression occurred in 19.0% of the 463 tumors tested. Using stepwise Cox proportional hazards regression modeling, multivariate analyses showed that the E2F-1 immunopositivity predicted more favorable survival as compared with the E2F-1 immunonegativity with borderline statistical significance [P = 0.050, hazard ratio (HR) = 0.702, 95% confidence interval, 0.487, 1.013]. However, the E2F-1 immunopositivity did not retain its statistical significance at multivariate analysis for predicting disease-free survival (data not shown, P = 0.270), but stage was the only influential factor for disease-free survival in stages IB to IV (M(0)) patients (P < 0.001). TS immunopositivity did not influence survival (P = 0.459) or disease-free survival (P = 0.447). CONCLUSION: E2F-1 is a potentially novel independent prognostic factor that may identify gastric cancer patients who will likely benefit from adjuvant chemoradiation therapy following curative resection.

Impact of E2F-1 Expression on Clinical Outcome of Gastric Adenocarcinoma Patients with Adjuvant Chemoradiation Therapy. Publishing Authors By Initials

J Lee,CK Park,JO Park,T Lim,YS Park,HY Lim,I Lee,TS Sohn,JH Noh,JS Heo,S Kim,do H Lim,KM Kim,WK Kang,J Lee,CK Park,JO Park,T Lim,YS Park,HY Lim,I Lee,TS Sohn,JH Noh,JS Heo,S Kim,do H Lim,KM Kim,WK Kang,J Lee,CK Park,JO Park,T Lim,YS Park,HY Lim,I Lee,TS Sohn,JH Noh,JS Heo,S Kim,do H Lim,KM Kim,WK Kang,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Impact of E2F-1 Expression on Clinical Outcome of Gastric Adenocarcinoma Patients with Adjuvant Chemoradiation Therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical cancer research : an official journal of

VOLUME: 14

Page Numbers: 82-8

Journal Abbreviation: Clin. Cancer Res.

ISSN: 1078-0432

DAY: 1

MONTH: Jan

YEAR: 2008

Impact of E2F-1 Expression on Clinical Outcome of Gastric Adenocarcinoma Patients with Adjuvant Chemoradiation Therapy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502500

Impact of E2F-1 Expression on Clinical Outcome of Gastric Adenocarcinoma Patients with Adjuvant Chemoradiation Therapy. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Impact of E2F-1 Expression on Clinical Outcome of Gastric Adenocarcinoma Patients with Adjuvant Chemoradiation Therapy. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Impact of E2F-1 Expression on Clinical Outcome of Gastric Adenocarcinoma Patients with Adjuvant Chemoradiation Therapy.

AFFILIATION: Authors' Affiliations: Division of Hematology-Oncology, Departments of Surgery, Radiation Oncology, and Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Impact of E2F-1 Expression on Clinical Outcome of Gastric Adenocarcinoma Patients with Adjuvant Chemoradiation Therapy Related Publications

• Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells.
• Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy.
• Behavioral models of Parkinson's disease in rodents: a new look at an old problem.
• Breast cancer risk and immune responses in healthy women.
• Calcineurin activation is not necessary for Doxorubicin-induced hypertrophy in H9c2 embryonic rat cardiac cells: involvement of the phosphoinositide 3-kinase-Akt pathway.
• Crystal structures and catalytic mechanism of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4.
• Crystal structures of vegetative soybean lipoxygenase VLX-B and VLX-D, and comparisons with seed isoforms LOX-1 and LOX-3.
• Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells.
• Gene transfer of the catabolic inhibitor TIMP-1 increases measured proteoglycans in cells from degenerated human intervertebral discs.
• Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids.
• Moyamoya disease with repeated intracranial haemorrhage in two consecutive pregnancies.
• Perceived stress among deaf adults.
• Production of inducible nitric oxide is required for monocytic differentiation of U937 cells induced by vitamin E-succinate.
• Synovial sarcoma of primary bone origin: a rare case in a rare site with atypical features.
• [A case of hemophagocytic syndrome with terminal ileal ulcerations]
• [Analysis and follow up research of 74 cases without psychosis in forensic psychiatric expertise]
• [Bonding behavior of 4f orbital]
• [Comparative study of room-temperature phosphorescence of 1-bromonaphthalene induced by synergetic effect of nonionic surfactants and beta-cyclodextrin]
• [Concept analysis of spiritual care]
• [Construction of urban green space ecosystem by using corridor network: a case study in west urban area of Dongying City, Shandong Province]
• [Correction of pediatric concealed penis by using a modified Devine' s technique]
• [Determination of Levofloxacin by chemiluminescence method]
• [Development of ELISA-kit of quantitative analysis for Zearalenone]
• [Dynamic study of anti-NS5 and ALT in post-transfusion hepatitis C]
• [Effects of constraint-induced movement using self-efficacy enhancing strategies on the upper extremity function of chronic hemiplegic patients]
• [Nicotine dependence, smoking-related attitude, and subjective norms across the stages of change for smoking cessation among adults smokers in a rural area]
• [Pathologic and X-ray features of primary malignant fibrous histiocytoma of bone--a report of 16 cases]
• [Percutaneous nephrolithotripsy with pneumatic and ultrasonic power under B-type ultrasound guidance for treatment of renal calculi in non-dilated collecting system]
• [Study on the silica-induced cytotoxicity and hprt gene mutagenisis in rat lung fibroblasts and alveolar type II epithelial cells]
• [The effects of cognitive behavioral anger management program on self-consciousness and anger in Korean military man]