Imp associates with squid and Hrp48 and contributes to localized expression of gurken in the oocyte.

Imp associates with squid and Hrp48 and contributes to localized expression of gurken in the oocyte. Research Abstract Details 

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Imp associates with squid and Hrp48 and contributes to localized expression of gurken in the oocyte. Abstract Text:

Cuiyun Geng,Paul M Macdonald,

Localization and translational control of Drosophila melanogaster gurken and oskar mRNAs rely on the hnRNP proteins Squid and Hrp48, which are complexed with one another in the ovary. Imp, the Drosophila homolog of proteins acting in localization of mRNAs in other species, is also associated with Squid and Hrp48. Notably, Imp is concentrated at sites of gurken and oskar mRNA localization in the oocyte, and alteration of gurken localization also alters Imp distribution. Imp binds gurken mRNA with high affinity in vitro; thus, the colocalization with gurken mRNA in vivo is likely to be the result of direct binding. Imp mutants support apparently normal regulation of gurken and oskar mRNAs. However, loss of Imp activity partially suppresses a gurken misexpression phenotype, indicating that Imp does act in control of gurken expression but has a largely redundant role that is only revealed when normal gurken expression is perturbed. Overexpression of Imp disrupts localization of gurken mRNA as well as localization and translational regulation of oskar mRNA. The opposing effects of reduced and elevated Imp activity on gurken mRNA expression indicate a role in gurken mRNA regulation.

Imp associates with squid and Hrp48 and contributes to localized expression of gurken in the oocyte. Publishing Authors By Initials

C Geng,PM Macdonald,

For similar peptides: intercellular signaling peptides and proteins: transforming growth factors: transforming growth factor alpha research abstracts see: peptides: intercellular signaling peptides and proteins: transforming growth factors: transforming growth factor alpha research

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Imp associates with squid and Hrp48 and contributes to localized expression of gurken in the oocyte. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular and cellular biology

VOLUME: 26

Page Numbers: 9508-16

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 0270-7306

DAY: 9

MONTH: 10

YEAR: 2006

Imp associates with squid and Hrp48 and contributes to localized expression of gurken in the oocyte. Information

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LANGUAGE: eng

NlmUniqueID: 8109087

Imp associates with squid and Hrp48 and contributes to localized expression of gurken in the oocyte. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor alpha

MESH TERMS: metabolism

Chemical & Substance for Abstract: Imp associates with squid and Hrp48 and contributes to localized expression of gurken in the oocyte. Information

Substance Name: squid protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for Imp associates with squid and Hrp48 and contributes to localized expression of gurken in the oocyte.

AFFILIATION: Institute for Cellular and Molecular Biology, Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, Austin, TX 78712-0159, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM54409

ACRONYM: GM

MEDLINETA: Mol Cell Biol

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