Immunotoxicity of bisphenol A to Carassius auratus lymphocytes and macrophages following in vitro exposure.

Immunotoxicity of bisphenol A to Carassius auratus lymphocytes and macrophages following in vitro exposure. Research Abstract Details 

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Immunotoxicity of bisphenol A to Carassius auratus lymphocytes and macrophages following in vitro exposure. Abstract Text:

Da-qiang Yin,Shuang-qing Hu,Ying Gu,Li Wei,Shu-shen Liu,Ai-qian Zhang,Da-qiang Yin,Shuang-qing Hu,Ying Gu,Li Wei,Shu-shen Liu,Ai-qian Zhang,Da-qiang Yin,Shuang-qing Hu,Ying Gu,Li Wei,Shu-shen Liu,Ai-qian Zhang,

Bisphenol A (BPA) is the monomer component of polycarbonate plastics and classified as an endocrine disrupting chemical (EDC). The reproductive toxicity of BPA has been extensively studied in mammals; however, relatively little information is available on the immunotoxic responses of fish to BPA. In this study, we investigated the effects of BPA on the immune functions of lymphocytes and macrophages in Carassius auratus. The effects of BPA were compared with those of two natural steroid hormones, estradiol and hydrocortisone. Proliferation of the two types of cells in response to PHA was measured using colorimetric MTT assay. Macrophage respiratory burst stimulated by Con A was measured using chemiluminescence assay. Results showed that BPA (0.054-5.4 mg/L), estradiol (0.0002-2.0 mg/L) and hydrocortisone (5-50 mg/L) significantly induced Carassius auratus lymphocyte proliferation while higher doses of hydrocortisone (500-5000 mg/L) appeared to be inhibitory. BPA (0.005-50 mg/L), estradiol (0.005-800 mg/L) and hydrocortisone (0.005-500 mg/L) markedly enhanced macrophage proliferation, whereas higher doses of BPA (500-1000 mg/L) appeared to inhibit cell proliferation. Furthermore, higher dosage of BPA (50 mg/L) and hydrocortisone (50 and 500 mg/L) suppressed the macrophages respiratory burst while estradiol is stimulative all the doses tested (0.05-500 mg/L). In conclusion, BPA could have immunotoxicity to Carassius auratus and functional changes of lymphocyte and macrophage in Carassius auratus may be different between low and high dosages.

Immunotoxicity of bisphenol A to Carassius auratus lymphocytes and macrophages following in vitro exposure. Publishing Authors By Initials

DQ Yin,SQ Hu,Y Gu,L Wei,SS Liu,AQ Zhang,DQ Yin,SQ Hu,Y Gu,L Wei,SS Liu,AQ Zhang,DQ Yin,SQ Hu,Y Gu,L Wei,SS Liu,AQ Zhang,

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Immunotoxicity of bisphenol A to Carassius auratus lymphocytes and macrophages following in vitro exposure. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of environmental sciences (China)

VOLUME: 19

Page Numbers: 232-7

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ISSN: 1001-0742

DAY: 5

MONTH: 10

YEAR: 2007

Immunotoxicity of bisphenol A to Carassius auratus lymphocytes and macrophages following in vitro exposure. Information

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LANGUAGE: eng

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AFFILIATION: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China. yindq@nju.edu.cn

Country: Netherlands

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MEDLINETA: J Environ Sci (China)

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