Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells.

Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells. Research Abstract Details 

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Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells. Abstract Text:

Dongshu Chen,Jianchuan Xia,Yasuhiro Tanaka,Hongsong Chen,Shigeo Koido,Oliver Wernet,Pinku Mukherjee,Sandra J Gendler,Donald Kufe,Jianlin Gong,

The tumour-associated antigen mucin 1 (MUC1) is a multifunctional protein involved in protection of mucous membranes, signal transduction, and modulation of the immune system. More than 70% of cancers overexpress MUC1, making MUC1 a potential target for immunotherapy. In the present study, MUC1 transgenic mice were crossed with syngeneic strains that express the polyomavirus middle-T oncogene (PyMT) driven by the mouse mammary tumour virus promoter long-terminal repeat (MMTV-LTR). The resultant breed (MMT mice) developed spontaneous MUC1-expressing mammary carcinomas with 100% penetrance at 8-15 weeks of age. As found in human breast cancer, the mammary carcinoma in MMT mice arose in multiple stages. Immunization with fusions of dendritic cells and MUC1-positive tumour cells (FC/MUC1) induced MUC1-specific immune responses that blocked or delayed the development of spontaneous breast carcinomas. In contrast, there was no delay of tumour development in MMT mice immunized with irradiated MC38/MUC1 tumour cells. The efficacy of fusion cells was closely correlated with the timing of initial immunization. Immunization with FC/MUC1 initiated in MMT mice at < 1, 1-2 and 2-3 months of age rendered 33, 5 and 0% of mice free of tumour, respectively, up to 6 months. Whereas mice immunized in the later stage of tumour development succumbed to their disease, immunization resulted in control of tumour progression and prolongation of life. These results indicate that immunization with FC/MUC1 can generate an anti-MUC1 response that is sufficient to delay the development of spontaneous mammary carcinomas and control tumour progression in MMT mice.

Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells. Publishing Authors By Initials

D Chen,J Xia,Y Tanaka,H Chen,S Koido,O Wernet,P Mukherjee,SJ Gendler,D Kufe,J Gong,

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Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Immunology

VOLUME: 109

Page Numbers: 300-7

Journal Abbreviation: Immunology

ISSN: 0019-2805

DAY: 1

MONTH: Jun

YEAR: 2003

Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells. Information

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LANGUAGE: eng

NlmUniqueID: 374672

Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells. Keywords Mesh Terms:

KEYWORDS: Peptide Fragments

MESH TERMS: metabolism

Chemical & Substance for Abstract: Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells. Information

Substance Name: Peptide Fragments

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Grant and Affiliation Information for Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells.

AFFILIATION: Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Country: England

AGENCY: United States NCI

GRANT: R01 CA87057

ACRONYM: CA

MEDLINETA: Immunology

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