Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia.

Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia. Abstract Text:

Valerie J Waters,Marisa I ,Grace Soong,Sunil Amin,Robert K Ernst,Alice Prince,

Stenotrophomonas maltophilia is a multiple-antibiotic-resistant opportunistic pathogen that is being isolated with increasing frequency from patients with health-care-associated infections and especially from patients with cystic fibrosis (CF). While clinicians feel compelled to treat infections involving this organism, its potential for virulence is not well established. We evaluated the immunostimulatory properties and overall virulence of clinical isolates of S. maltophilia using the well-characterized opportunistic pathogen Pseudomonas aeruginosa PAO1 as a control. The properties of CF isolates were examined specifically to see if they have a common phenotype. The immunostimulatory properties of S. maltophilia were studied in vitro by stimulating airway epithelial and macrophage cell lines. A neonatal mouse model of pneumonia was used to determine the rates of pneumonia, bacteremia, and mortality, as well as the inflammatory response elicited by S. maltophilia infection. Respiratory and nonrespiratory S. maltophilia isolates were highly immunostimulatory and elicited significant interleukin-8 expression by airway epithelial cells, as well as tumor necrosis factor alpha (TNF-alpha) expression by macrophages. TNF-alpha signaling appears to be important in the pathogenesis of S. maltophilia infection as less than 20% of TNFR1 null mice (compared with 100% of wild-type mice) developed pneumonia and bacteremia following intranasal inoculation. The S. maltophilia isolates were weakly invasive, and low-level bacteremia with no mortality was observed. Despite the lack of invasiveness of S. maltophilia, the immunostimulatory properties of this organism and its induction of TNF-alpha expression specifically indicate that it is likely to contribute significantly to airway inflammation.

Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia. Publishing Authors By Initials

VJ Waters,MI ,G Soong,S Amin,RK Ernst,A Prince,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

PUBMED ID PMID:

MEDLINE DATE:

Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Infection and immunity

VOLUME: 75

Page Numbers: 1698-703

Journal Abbreviation: Infect. Immun.

ISSN: 0019-9567

DAY: 12

MONTH: 01

YEAR: 2007

Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 246127

Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia. Information

Substance Name: Tumor Necrosis Factor-alpha

Registry Number: 0

Grant and Affiliation Information for Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia.

AFFILIATION: College of Physicians and Surgeons, Columbia University, 650 W. 168th Street, BB 4-416, New York, NY 10032, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK 36393

ACRONYM: DK

MEDLINETA: Infect Immun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia Related Publications

• A new satellite technology for tracking the movements of atlantic bluefin tuna.
• A role for Tbx2 in the regulation of the alpha2(1) collagen gene in human fibroblasts.
• An advance in colour photomicrography of the living eye.
• Automatic 3D tracking of cardiac material markers using slice-following and harmonic-phase MRI.
• Bone mass in young women is dependent on lean body mass.
• Comparison of speech production in upright and supine position.
• Consequences of Hoxb1 duplication in teleost fish.
• Cortical surface alignment using geometry driven multispectral optical flow.
• Epigenetic targets in hematological malignancies: combination therapies with HDACis and demethylating agents.
• Fatty acids ofLindera umbellata and other Lauraceae seed oils.
• Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia.
• Immunotherapy of multiple myeloma: the start of a long and tortuous journey.
• Is there replacement for percentage stenosis in characterizing occlusive vascular disease?
• Markers of inflammation and cognitive decline in an African-Caribbean population.
• Multi-slice three-dimensional myocardial strain tensor quantification using zHARP.
• Opportunistic infections in lung disease: Pseudomonas infections in cystic fibrosis.
• Origin of the zebrafish endocrine and exocrine pancreas.
• Pathways to homelessness among older people in Rio de Janeiro, Brazil.
• Prevalence of depressive symptoms and syndromes in later life in ten European countries: the SHARE study.
• Real-time monitoring of cardiac regional function using fastHARP MRI and region-of-interest reconstruction.
• Safety and efficacy of combining ATRA with G-CSF in HSPC mobilization; a pilot study in multiple myeloma and non-Hodgkin's lymphoma patients.
• Staphylococcus aureus protein A activates TACE through EGFR-dependent signaling.
• Successful treatment of Behçet's disease with lenalidomide.
• Tea drinking is associated with benefits on bone density in older women.
• Tea intake is inversely related to blood pressure in older women.
• Toward optimal matching for 3D reconstruction of brachytherapy seeds.
• Treatment of primary cutaneous follicular centre lymphoma with rituximab: A report of two cases.
• ZHARP: three-dimensional motion tracking from a single image plane.
• Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b.
• [Stress and prevention in the recurrence of coronary heart disease.]