Immunostimulating and antineoplastic activities of staphylococcal lipoteichoic acid (LTA) were studied in Balb/c-mice. Systemic administration of LTA (1 mg or 2 mg i. p., 7 and 4 days prior to challenge) significantly enhanced chemiluminescence response of peritoneal macrophages (p less than 0.0125) and induced enlargement of the spleen (p less than 0.025) as compared to non-treated controls. In vivo the number of lung colonies was significantly lower (p less than 0.0125) in LTA-treated mice 14 days after challenge with L-1 sarcoma cells.
Immunostimulating staphylococcal lipoteichoic acid prevents pulmonary tumor colonization in BALB/c-mice. Publishing Authors By Initials
Chemical & Substance for Abstract: Immunostimulating staphylococcal lipoteichoic acid prevents pulmonary tumor colonization in BALB/c-mice. Information
Substance Name: lipoteichoic acid
Registry Number: 56411-57-5
Grant and Affiliation Information for Immunostimulating staphylococcal lipoteichoic acid prevents pulmonary tumor colonization in BALB/c-mice.
AFFILIATION: Institute of Hygiene, University of Cologne, Köln.
Country: GERMANY, WEST
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MEDLINETA: Zentralbl Bakteriol Mikrobiol
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