Immunosenescence and age-related susceptibility to influenza virus in Japanese quail.

Immunosenescence and age-related susceptibility to influenza virus in Japanese quail. Research Abstract Details 

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Immunosenescence and age-related susceptibility to influenza virus in Japanese quail. Abstract Text:

Emma T Lavoie,Erin M Sorrell,Daniel R Perez,Mary Ann Ottinger,

We evaluated juvenile, pubescent, reproductive adult, and aged Japanese quail (Coturnix coturnix japonica) to determine if there were age-related differences in immune function with the hypothesis that aged birds would have weaker immune responses. Immune responses were measured using phytohemagglutinin (PHA) skin test, antibody response to foreign red blood cells and exposure to an H9N2 influenza virus. Adult birds consistently had stronger immune responses than young and aged birds. Aged quail had skin responses 38% lower than adults. Pubescent birds' mean anti-red blood cell response was four-fold lower than adult birds. Adults had greater increase in total anti-viral antibody between primary and secondary infections than all other groups. Our data demonstrate an age-related difference in immune function in Japanese quail that has similarities to age-related immunity in humans; younger and older animals had weaker immune responses compared to young adults.

Immunosenescence and age-related susceptibility to influenza virus in Japanese quail. Publishing Authors By Initials

ET Lavoie,EM Sorrell,DR Perez,MA Ottinger,

For similar diagnosis: diagnostic techniques and procedures: skin tests research abstracts see: diagnosis: diagnostic techniques and procedures: skin tests research

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Immunosenescence and age-related susceptibility to influenza virus in Japanese quail. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Developmental and comparative immunology

VOLUME: 31

Page Numbers: 407-14

Journal Abbreviation: Dev. Comp. Immunol.

ISSN: 0145-305X

DAY: 20

MONTH: 09

YEAR: 2006

Immunosenescence and age-related susceptibility to influenza virus in Japanese quail. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7708205

Immunosenescence and age-related susceptibility to influenza virus in Japanese quail. Keywords Mesh Terms:

KEYWORDS: Skin Tests

MESH TERMS: immunology

Chemical & Substance for Abstract: Immunosenescence and age-related susceptibility to influenza virus in Japanese quail. Information

Substance Name: Phytohemagglutinins

Registry Number: 0

Grant and Affiliation Information for Immunosenescence and age-related susceptibility to influenza virus in Japanese quail.

AFFILIATION: Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA. elavoie@umd.edu

Country: United States

AGENCY: United States NIAID

GRANT: 1R01AI052155

ACRONYM: AI

MEDLINETA: Dev Comp Immunol

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