Immunoscintigraphy of melanoma using radiolabelled antibodies: pilot, prospective studies and Italian multicenter clinical trials.

Immunoscintigraphy of melanoma using radiolabelled antibodies: pilot, prospective studies and Italian multicenter clinical trials. Research Abstract Details 

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Immunoscintigraphy of melanoma using radiolabelled antibodies: pilot, prospective studies and Italian multicenter clinical trials. Abstract Text:

G L Buraggi,M Gasparini,

The studies on radioimmunodetection of malignant melanoma reported are based on the use of the 225.28S monoclonal antibody against a high molecular weight melanoma associated antigen, an IgG2a isolated and characterized by Ferrone et al. The strategy followed by us to check the characteristics and the behaviour of this antibody and to verify its possible use in clinical praxis, includes three groups of trials performed from 1982 to 1987. A pilot study was performed on 42 patients with 74 melanoma lesions, a multicenter study was realized, with the collaboration of 10 Italian nuclear medicine centers, on 254 patients with 539 lesions and prospective study performed on 44 patients with 54 suspected regional lymph nodes involvements. High sensitivity and specificity were obtained especially with the use of technetium compound which also allowed the attainment of very high predictive values of positive tests. No adverse reactions were noticed.

Immunoscintigraphy of melanoma using radiolabelled antibodies: pilot, prospective studies and Italian multicenter clinical trials. Publishing Authors By Initials

GL Buraggi,M Gasparini,

For similar inorganic chemicals: isotopes: radioisotopes research abstracts see: inorganic chemicals: isotopes: radioisotopes research

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Immunoscintigraphy of melanoma using radiolabelled antibodies: pilot, prospective studies and Italian multicenter clinical trials. Journal Published:

PUBLICATION TYPE: Review

Journal: International journal of radiation applications an

VOLUME: 16

Page Numbers: 629-32

Journal Abbreviation:

ISSN: 0883-2897

DAY: 21

MONTH: 02

YEAR: 1989

Immunoscintigraphy of melanoma using radiolabelled antibodies: pilot, prospective studies and Italian multicenter clinical trials. Information

Number of References: 16

LANGUAGE: eng

NlmUniqueID: 8611098

Immunoscintigraphy of melanoma using radiolabelled antibodies: pilot, prospective studies and Italian multicenter clinical trials. Keywords Mesh Terms:

KEYWORDS: Radioisotopes

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Immunoscintigraphy of melanoma using radiolabelled antibodies: pilot, prospective studies and Italian multicenter clinical trials. Information

Substance Name: Radioisotopes

Registry Number: 0

Grant and Affiliation Information for Immunoscintigraphy of melanoma using radiolabelled antibodies: pilot, prospective studies and Italian multicenter clinical trials.

AFFILIATION: Nuclear Medicine Division, Istituto Nazionale Tumori, Milano, Italy.

Country: UNITED STATES

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MEDLINETA: Int J Rad Appl Instrum B

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