Immunoregulation in pancreatic cancer patients.

Immunoregulation in pancreatic cancer patients. Research Abstract Details 

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Immunoregulation in pancreatic cancer patients. Abstract Text:

J M Plate,S Shott,J E Harris,

Metastatic pancreatic cancer is one of the most aggressive cancer known in man yet specific antitumor immunity has been demonstrated in lymph nodes draining the sites of pancreatic tumors. Despite this immunity, pancreatic cancer patients suffer a quick demise. To further define tumor immunity in patients with metastatic pancreatic cancer, we sought to characterize helper T cell subsets, serum cytokines, cellular cytotoxicity that is both T-cell and non-T cell mediated, as well as known tumor-derived immunosuppressive products that may be present in their peripheral blood. Significantly heightened levels of interleukin 2 (IL-2), a Th1 cytokine, were found in patients before treatment with chemotherapy while serum IL-10, a Th2 cytokine, were at significantly lower levels than observed in normal donors tested between their fifth and seventh decades of life. IL-10 levels increased progressively with age as a serum-bound protein in normal, healthy donors tested between the ages of 24 through 61. An age associated progression of increased IL-10 levels was not observed in pancreatic cancer patients. Few patients had detectable serum levels of soluble fas ligand but approximately half had elevated levels of a tumor marker, detected with the CA-15.3 assay, known as soluble MUCIN 1 (MUC1). Cell mediated cytotoxicity including T-cell mediated killing of pancreatic tumor cell lines was detected in many patients. These data suggest that pancreatic cancer patients have activated type 1 helper T cells that can support development of cell-mediated immunity, and that their sera contain lowered levels of the "anti-inflammatory" type 2 cytokine, IL-10.

Immunoregulation in pancreatic cancer patients. Publishing Authors By Initials

JM Plate,S Shott,JE Harris,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, helper-inducer: th2 cells research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, helper-inducer: th2 cells research

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Immunoregulation in pancreatic cancer patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer immunology, immunotherapy : CII

VOLUME: 48

Page Numbers: 270-9

Journal Abbreviation: Cancer Immunol. Immunother.

ISSN: 0340-7004

DAY: 1

MONTH: Aug

YEAR: 1999

Immunoregulation in pancreatic cancer patients. Information

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LANGUAGE: eng

NlmUniqueID: 8605732

Immunoregulation in pancreatic cancer patients. Keywords Mesh Terms:

KEYWORDS: Th2 Cells

MESH TERMS: immunology

Chemical & Substance for Abstract: Immunoregulation in pancreatic cancer patients. Information

Substance Name: Interleukin-10

Registry Number: 130068-27-8

Grant and Affiliation Information for Immunoregulation in pancreatic cancer patients.

AFFILIATION: Section of Medical Oncology, Department of Medicine, Rush-Presbyterian St. Luke's Medical Center, Chicago, IL 60612, USA. jplate@sispro.sis.rpslmc.edu

Country: GERMANY

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MEDLINETA: Cancer Immunol Immunother

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