Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions.

Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions. Research Abstract Details 

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Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions. Abstract Text:

BACKGROUND/AIMS: The authors investigated the expression of S100A1, S100A6, S100B, MelanA, and CEA in conjunctival naevi, primary acquired melanosis (PAM), conjunctival melanoma, and uveal melanoma in order to assess their potential usefulness in the pathological differential diagnosis of these entities. METHODS: Paraffin embedded sections of 18 conjunctival naevi, 14 PAM, 16 conjunctival melanomas, and 20 uveal melanomas were immunostained for S100A1, S100A6, S100B, MelanA, and CEA, and expression was scored semiquantitatively. RESULTS: Expression of S100A1 differed significantly between conjunctival naevi and conjunctival melanoma, with percentages of positive cells of 30.6% and 71.4%, respectively. Conjunctival melanomas had high average scores for S100A1 and S100B (71.4%, 62.9%, respectively), while uveal melanomas also had high S100A1 but low S100B scores (88.5%, 18.5%, respectively). MelanA was highly variable; naevi and uveal melanoma had higher average scores than conjunctival melanoma. CEA was hardly detectable in all four groups. CONCLUSION: S100A1 seems to be a possible candidate to differentiate conjunctival naevi from conjunctival melanoma. S100B seems to differentiate between uveal melanoma and conjunctival melanoma. However, the study size was small and therefore the data have to be confirmed by others.

Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions. Publishing Authors By Initials

For similar neoplasms: neoplasms by site: eye neoplasms: uveal neoplasms research abstracts see: neoplasms: neoplasms by site: eye neoplasms: uveal neoplasms research

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Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The British journal of ophthalmology

VOLUME: 90

Page Numbers: 213-7

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Feb

YEAR: 2006

Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions. Keywords Mesh Terms:

KEYWORDS: Uveal Neoplasms

MESH TERMS: immunology

Chemical & Substance for Abstract: Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions. Information

Substance Name: S100A6 protein, human

Registry Number: 105504-00-5

Grant and Affiliation Information for Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions.

AFFILIATION: Department of Ophthalmology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands.

Country: England

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MEDLINETA: Br J Ophthalmol

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