Immunophenotypes in the circulation of patients with mild cognitive impairment.

Immunophenotypes in the circulation of patients with mild cognitive impairment. Research Abstract Details 

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Immunophenotypes in the circulation of patients with mild cognitive impairment. Abstract Text:

Shino Magaki,Steven M Yellon,Claudius Mueller,Wolff M Kirsch,

Alterations in the peripheral immune system are associated with dementia and the neuropathology of Alzheimer's disease, but have yet to be studied early in the disease process. To test the hypothesis that the balance of immune cell phenotypes is disrupted in the early progression of memory deterioration, patients with mild cognitive impairment (MCI) and healthy elderly controls were examined for the distribution of subpopulations of leukocytes (lymphocytes, granulocytes, and monocytes) and lymphocyte subtypes (helper/inducer and suppressor/cytotoxic T lymphocytes and B lymphocytes) in blood. MCI subjects had a significantly higher percentage of total lymphocytes and a lower percentage of granulocytes compared to elderly controls. Furthermore, the expression of cell surface amyloid precursor protein (APP) and intracellular amyloid-beta peptide (Abeta) in lymphocytes and monocytes were determined. We found lymphocyte APP expression to be significantly increased in MCI subjects compared to controls. Our data indicate that changes in immunological parameters may be detected early in MCI, and an alteration of the immune response may precede clinical AD.

Immunophenotypes in the circulation of patients with mild cognitive impairment. Publishing Authors By Initials

S Magaki,SM Yellon,C Mueller,WM Kirsch,

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Immunophenotypes in the circulation of patients with mild cognitive impairment. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of psychiatric research

VOLUME: 42

Page Numbers: 240-6

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ISSN: 0022-3956

DAY: 23

MONTH: 02

YEAR: 2007

Immunophenotypes in the circulation of patients with mild cognitive impairment. Information

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LANGUAGE: eng

NlmUniqueID: 376331

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Grant and Affiliation Information for Immunophenotypes in the circulation of patients with mild cognitive impairment.

AFFILIATION: Center for Neurosurgery Research, Coleman Pavilion, Suite 11113, 11175 Campus Street, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.

Country: England

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MEDLINETA: J Psychiatr Res

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