Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitro.

Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitro. Research Abstract Details 

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Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitro. Abstract Text:

Lan Wu,Weige Zhang,Liang Tian,Kai Bao,Pengfei Li,Jie Lin,Lan Wu,Weige Zhang,Liang Tian,Kai Bao,Pengfei Li,Jie Lin,Lan Wu,Weige Zhang,Liang Tian,Kai Bao,Pengfei Li,Jie Lin,

To elucidate the immunomodulatory mechanisms of macrolides, we investigated here the effects of erythromycin (EM) and its derivatives, 1 and 2, which show no antibacterial activity, on the proliferation and the activation of the transcription factor nuclear factor-kappaB (NF-kappaB) in Jurkat T cells. MTT assay revealed that EM, 1 and 2 could inhibit T lymphocyte proliferation markedly. Flow cytometry and TUNEL analysis showed EM (30 mug/mL-100 mug/mL) and 1 (3 mug/mL-30 mug/mL) could induce T lymphocyte apoptosis, 2 (3 mug/mL-30 mug/mL) induced a cell cycle arrest in G(2)/M. RT-PCR and Western blotting analysis conformed that EM and its two derivatives could inhibit the expressions of NF-kappaB mRNA and protein. Taken together, these data suggest EM and its derivatives, 1 and 2, have immunomodulatory effect, presumably via an interaction with the NF-kappaB expression, inhibiting the proliferation of T lymphocyte, implicating an approach for the development of new drugs for treating inflammatory diseases.

Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitro. Publishing Authors By Initials

L Wu,W Zhang,L Tian,K Bao,P Li,J Lin,L Wu,W Zhang,L Tian,K Bao,P Li,J Lin,L Wu,W Zhang,L Tian,K Bao,P Li,J Lin,

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Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitro. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Immunopharmacology and immunotoxicology

VOLUME: 29

Page Numbers: 587-96

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ISSN: 0892-3973

DAY: 13

MONTH: 12

YEAR: 2007

Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitro. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitro.

AFFILIATION: Department of Geratology, The First Affiliated Hospital, Chinese Medical University, Shenyang, P.R. China.

Country: United States

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MEDLINETA: Immunopharmacol Immunotoxicol

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