Immunological role of human palatine tonsil in Epstein-Barr virus persistence.

Immunological role of human palatine tonsil in Epstein-Barr virus persistence. Research Abstract Details 

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Immunological role of human palatine tonsil in Epstein-Barr virus persistence. Abstract Text:

M Hirao,Y Harabuchi,A Kataura,S Imai,T Osato,

To determine whether EBV-specific cellular immunity persists and controls EBV in the palatine tonsil, we compared EBV-specific cellular immune responses in the palatine tonsil and peripheral blood. In 32 EBV-seropositive donors, we performed in vitro growth inhibition assays of EBV-induced B-lymphocyte transformation (regression assay). The results showed that EBV-specific cytotoxic T lymphocytes (CTL) precursor frequency was higher in the palatine tonsil than in the peripheral blood. After a first stimulation with autologous lymphoblastoid cell line (LCL), the EBV-specific cytotoxicity of reactivated CTL was higher in the palatine tonsil than in the peripheral blood. Furthermore EBV-specific CTL lines established from the palatine tonsil had significantly higher EBV-specific cytotoxicity in comparison with those from the peripheral blood. Both the EBV-specific CTLs from tonsils and peripheral blood were restricted by HLA class-I determinants. These data indicate that the palatine tonsil, which is frequently exposed to EBV, plays an important role in controlling EBV infection in the oropharynx.

Immunological role of human palatine tonsil in Epstein-Barr virus persistence. Publishing Authors By Initials

M Hirao,Y Harabuchi,A Kataura,S Imai,T Osato,

For similar stomatognathic diseases: pharyngeal diseases: tonsillitis research abstracts see: stomatognathic diseases: pharyngeal diseases: tonsillitis research

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Immunological role of human palatine tonsil in Epstein-Barr virus persistence. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta oto-laryngologica. Supplementum

VOLUME: 523

Page Numbers: 158-60

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ISSN: 0365-5237

DAY: 13

MONTH: 02

YEAR: 1996

Immunological role of human palatine tonsil in Epstein-Barr virus persistence. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Immunological role of human palatine tonsil in Epstein-Barr virus persistence. Keywords Mesh Terms:

KEYWORDS: Tonsillitis

MESH TERMS: virology

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Grant and Affiliation Information for Immunological role of human palatine tonsil in Epstein-Barr virus persistence.

AFFILIATION: Department of Otolaryngology, School of Medicine, Sapporo Medical University, Sapporo, Japan.

Country: NORWAY

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MEDLINETA: Acta Otolaryngol Suppl

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