[Immunologic and cytogenetic aspects of ataxia telangiectasia]

[Immunologic and cytogenetic aspects of ataxia telangiectasia] Research Abstract Details 

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[Immunologic and cytogenetic aspects of ataxia telangiectasia] Abstract Text:

C M Weemaes,R D Taalman,P J Van Munster,T W Hustinx,J A Bakkeren,J M Scheres,

Immunological and cytogenetic studies were performed in 6 patients with ataxia telangiectasia (AT). Immunological disturbances were found in these patients: immunoglobulin deficiencies (IgA, IgE, IgG2 and IgG4), decreased cellular immunity and a defect in the synthesis of specific antibodies. Cytogenetic studies revealed chromosome 7 and/or 14 abnormalities in all patients. X-irradiation of AT cells induced an excessive increase in chromosome and chromatid breaks. The DNA synthesis inhibition after X rays was less in AT patients compared to controls. The possibilities of early diagnosis and the eventual relationship between immunological and cytogenetic findings are discussed.

[Immunologic and cytogenetic aspects of ataxia telangiectasia] Publishing Authors By Initials

CM Weemaes,RD Taalman,PJ Van Munster,TW Hustinx,JA Bakkeren,JM Scheres,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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[Immunologic and cytogenetic aspects of ataxia telangiectasia] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Tijdschrift voor kindergeneeskunde

VOLUME: 52

Page Numbers: 164-9

Journal Abbreviation: Tijdschr Kindergeneeskd

ISSN: 0376-7442

DAY: 24

MONTH: Aug

YEAR: 1984

[Immunologic and cytogenetic aspects of ataxia telangiectasia] Information

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LANGUAGE: dut

NlmUniqueID: 7704039

[Immunologic and cytogenetic aspects of ataxia telangiectasia] Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: immunology

Chemical & Substance for Abstract: [Immunologic and cytogenetic aspects of ataxia telangiectasia] Information

Substance Name: Immunoglobulins

Registry Number: 0

Grant and Affiliation Information for [Immunologic and cytogenetic aspects of ataxia telangiectasia]

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Country: NETHERLANDS

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MEDLINETA: Tijdschr Kindergeneeskd

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