Immunologic abnormalities in alcoholic hepatitis.

Immunologic abnormalities in alcoholic hepatitis. Research Abstract Details 

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Immunologic abnormalities in alcoholic hepatitis. Abstract Text:

There are many unanswered questions in the possible autoimmune pathogenesis of alcoholic liver disease. Why do only 15-20% of chronic alcoholic patients develop alcoholic hepatitis and cirrhosis? What factors make a patient susceptible to immune events in alcoholism? What initiates immune reactivity in susceptible patients? What permits accumulation of alcoholic hyalin in patients with alcoholic hepatitis? Is alcoholic hyalin central to the pathogenesis of alcoholic hepatitis? If adducts play a role, why don't more alcoholics develop liver disease, as adducts probably form in all patients? Unfortunately, the lack of an appropriate animal model will probably allow these questions to remain unanswered for some time. However, further research into the role of adducts in alcoholic liver disease may be helpful. Isolation of adducts from hepatocytes of patients with alcoholic hepatitis may permit study of their intracellular location, formation and perhaps of their timing in the sequence of liver disease. These studies should provide additional clues to the pathogenesis of alcoholic liver disease.

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Immunologic abnormalities in alcoholic hepatitis. Journal Published:

PUBLICATION TYPE: Review

Journal: Alcohol and alcoholism (Oxford, Oxfordshire). Supp

VOLUME: 1

Page Numbers: 305-10

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ISSN: 1358-6173

DAY: 26

MONTH: 02

YEAR: 1991

Immunologic abnormalities in alcoholic hepatitis. Information

Number of References: 20

LANGUAGE: eng

NlmUniqueID: 8804836

Immunologic abnormalities in alcoholic hepatitis. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Immunologic abnormalities in alcoholic hepatitis. Information

Substance Name: Acetaldehyde

Registry Number: 75-07-0

Grant and Affiliation Information for Immunologic abnormalities in alcoholic hepatitis.

AFFILIATION: University of Nebraska Medical Center, Omaha 68198-2000.

Country: ENGLAND

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MEDLINETA: Alcohol Alcohol Suppl

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