Immunolocalization of cell signaling molecules in the granular cell ameloblastoma.

Immunolocalization of cell signaling molecules in the granular cell ameloblastoma. Research Abstract Details 

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Immunolocalization of cell signaling molecules in the granular cell ameloblastoma. Abstract Text:

Gul San Ara Sathi,Phuu Pwint Han,Ryo Tamamura,Hitoshi Nagatsuka,Hailong Hu,Naoki Katase,Noriyuki Nagai,Gul San Ara Sathi,Phuu Pwint Han,Ryo Tamamura,Hitoshi Nagatsuka,Hailong Hu,Naoki Katase,Noriyuki Nagai,

BACKGROUND: Bone morphogenic protein (BMP) and Wnt signaling pathway molecules play important roles in cytodifferentiation and cell proliferation. We attempted to localize these signaling molecules in the granular cell ameloblastoma. MATERIALS AND METHODS: Four samples of paraffin-embedded ameloblastoma with granular cells were studied. Immunohistochemistry was performed to detect basement membrane type heparan sulfate (HS) (JM403), cell surface type HS (10E4), heparanase, Wnt-5a, Wnt-2, beta-catenin, and BMP-4. RESULTS: In all four samples, strong expression of beta-catenin and Wnt-5a was detected within the granular cells, while BMP-4 expression was weak and Wnt-2 was negative. Immunoreactivities of basement membrane type HS, cell surface type HS, and heparanase were variable within granular cells in ameloblastoma. CONCLUSION: Granular cells in ameloblastoma exhibit abnormal biological behaviors, particularly synthesis and secretion of protein. Synthesis of signaling molecules is upregulated, but secretion is arrested in some cases, while both are lost in other cases.

Immunolocalization of cell signaling molecules in the granular cell ameloblastoma. Publishing Authors By Initials

GS Sathi,PP Han,R Tamamura,H Nagatsuka,H Hu,N Katase,N Nagai,GS Sathi,PP Han,R Tamamura,H Nagatsuka,H Hu,N Katase,N Nagai,

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Immunolocalization of cell signaling molecules in the granular cell ameloblastoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of oral pathology & medicine : official pu

VOLUME: 36

Page Numbers: 609-14

Journal Abbreviation: J. Oral Pathol. Med.

ISSN: 0904-2512

DAY: 19

MONTH: Nov

YEAR: 2007

Immunolocalization of cell signaling molecules in the granular cell ameloblastoma. Information

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LANGUAGE: eng

NlmUniqueID: 8911934

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Grant and Affiliation Information for Immunolocalization of cell signaling molecules in the granular cell ameloblastoma.

AFFILIATION: Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Country: Denmark

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MEDLINETA: J Oral Pathol Med

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