Immunohistologic studies in pityriasis rosea. Evidence for cellular immune reaction in the lesional epidermis.

Immunohistologic studies in pityriasis rosea. Evidence for cellular immune reaction in the lesional epidermis. Research Abstract Details 

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Immunohistologic studies in pityriasis rosea. Evidence for cellular immune reaction in the lesional epidermis. Abstract Text:

Biopsy specimens of the skin lesions of pityriasis rosea obtained from 15 patients were studied. Characteristic histologic changes were composed of focal intercellular edema, epidermotropism of mononuclear cells often associated with the formation of focal intraepidermal collections of mononuclear cells, and of a perivascular lymphohistiocytic cell infiltration in the superficial dermis. Immunologic analysis using monoclonal antibodies showed that large numbers of lymphoid cells in the perivascular infiltrate reacted with anti-pan-T-cell, anti-helper-inducer subset, and anti-HLA-DR monoclonal antibodies, while the epidermotropic mononuclear cells consisted of helper-inducer cells or suppressor-cytotoxic cells without any predominance pattern. In addition to epidermal Langerhans' cells, some of the dermal infiltrating cells were reactive with monoclonal antibody OKT6. Moreover, there was localized expression of HLA-DR antigen on the keratinocytes. We think that cellular immune reactions are taking place in the lesional epidermis of pityriasis rosea.

Immunohistologic studies in pityriasis rosea. Evidence for cellular immune reaction in the lesional epidermis. Publishing Authors By Initials

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Immunohistologic studies in pityriasis rosea. Evidence for cellular immune reaction in the lesional epidermis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatology

VOLUME: 121

Page Numbers: 761-5

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Jun

YEAR: 1985

Immunohistologic studies in pityriasis rosea. Evidence for cellular immune reaction in the lesional epidermis. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Immunohistologic studies in pityriasis rosea. Evidence for cellular immune reaction in the lesional epidermis. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: immunology

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Substance Name: Histocompatibility Antigens Class II

Registry Number: 0

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Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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