Immunohistochemistry and in situ hybridization of T-cell acute lymphoblastic leukemia-associated antigen 1 in human brain tissues.

Immunohistochemistry and in situ hybridization of T-cell acute lymphoblastic leukemia-associated antigen 1 in human brain tissues. Research Abstract Details 

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Immunohistochemistry and in situ hybridization of T-cell acute lymphoblastic leukemia-associated antigen 1 in human brain tissues. Abstract Text:

T Yamada,Y Tsujioka,M Takahashi,Y Tsuboi,J Taguchi,O Yoshie,

One of the proteins belonging to the transmembrane 4 superfamily, T-cell acute lymphoblastic leukemia-associated antigen 1 (TALLA1), behaves like a potential tumor-associated antigen. Furthermore, its mRNA is expressed in normal brain. We examined here the histochemical localization of the protein and its mRNA in human brain tissues. Both nonneurological and Alzheimer disease (AD) brains showed astroglial staining for the TALLA1 molecule. In AD brain tissues, globular dystrophic neurites were positively stained. In damaged white matter showing leukoaraiosis by CT scan there was varicose axonal staining with the anti-TALLA1 antibody. In situ hybridization histochemistry using a RNA probe demonstrated neuronal expression of the mRNA. These results suggest that TALLA1, like amyloid precursor protein or chromogranin A, is produced in neurons and transported by axonal flow.

Immunohistochemistry and in situ hybridization of T-cell acute lymphoblastic leukemia-associated antigen 1 in human brain tissues. Publishing Authors By Initials

T Yamada,Y Tsujioka,M Takahashi,Y Tsuboi,J Taguchi,O Yoshie,

For similar nervous system: neurons: senile plaques research abstracts see: nervous system: neurons: senile plaques research

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MEDLINE DATE: 1999 Mar-Apr

Immunohistochemistry and in situ hybridization of T-cell acute lymphoblastic leukemia-associated antigen 1 in human brain tissues. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Dementia and geriatric cognitive disorders

VOLUME: 10

Page Numbers: 59-63

Journal Abbreviation: Dement Geriatr Cogn Disord

ISSN: 1420-8008

DAY: 24

MONTH: 03

YEAR: 2008

Immunohistochemistry and in situ hybridization of T-cell acute lymphoblastic leukemia-associated antigen 1 in human brain tissues. Information

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LANGUAGE: eng

NlmUniqueID: 9705200

Immunohistochemistry and in situ hybridization of T-cell acute lymphoblastic leukemia-associated antigen 1 in human brain tissues. Keywords Mesh Terms:

KEYWORDS: Senile Plaques

MESH TERMS: pathology

Chemical & Substance for Abstract: Immunohistochemistry and in situ hybridization of T-cell acute lymphoblastic leukemia-associated antigen 1 in human brain tissues. Information

Substance Name: thymus-leukemia antigens

Registry Number: 0

Grant and Affiliation Information for Immunohistochemistry and in situ hybridization of T-cell acute lymphoblastic leukemia-associated antigen 1 in human brain tissues.

AFFILIATION: Department of Internal Medicine and Health Care, Fukuoka University, Fukuoka, Japan.

Country: SWITZERLAND

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MEDLINETA: Dement Geriatr Cogn Disord

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