Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis.

Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. Research Abstract Details 

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Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. Abstract Text:

Murat Dogru,Naoko Kato,Yukihiro Matsumoto,Yoichi Tanaka,Naoko Akabane,Shigeto Shimmura,Kazuo Tsubota,Jun Shimazaki,Murat Dogru,Naoko Kato,Yukihiro Matsumoto,Yoichi Tanaka,Naoko Akabane,Shigeto Shimmura,Kazuo Tsubota,Jun Shimazaki,

PURPOSE: To describe the immunohistochemical and electron microscopic characteristics of retrocorneal scrolls in syphilitic interstitial keratitis. METHODS: Five eyes of five patients with congenital syphilitic interstitial keratitis who underwent keratoplasty for corneal opacities and corneal edema were studied. The corneal buttons were processed for histologic examination with hematoxylin and eosin staining and underwent immunohistochemistry stainings for collagen types I, III, IV, V, VI, VIII, fibronectin, laminin, and decorin. The corneal buttons were also processed for transmission electron microscopy and immunoelectron microscopy. RESULTS: Light microscopy revealed that the retrocorneal scrolls had a multilayered, amorphous, acellular matrix. All scrolls were lined with attenuated corneal endothelial cells. The Descemet membranes in all specimens had areas of irregular thickening with attenuated endothelium. Immunohistochemical assessment of the scrolls showed positive staining for collagens I, III, IV, VI, VIII, fibronectin, laminin, and decorin but not for alpha -SMA. Immunoelectron microscopy confirmed these findings. Transmission electron microscopy showed multilaminar disorganized structures in scrolls composed of long- and short-fiber collagens. CONCLUSIONS: We confirmed the presence of collagens I, III, IV, VI, VIII and proteoglycans in the retrocorneal scrolls lined with attenuated endothelium. Our findings may provide further insight into the pathogenesis of keratopathy in syphilitic interstitial keratitis.

Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. Publishing Authors By Initials

M Dogru,N Kato,Y Matsumoto,Y Tanaka,N Akabane,S Shimmura,K Tsubota,J Shimazaki,M Dogru,N Kato,Y Matsumoto,Y Tanaka,N Akabane,S Shimmura,K Tsubota,J Shimazaki,

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Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current eye research

VOLUME: 32

Page Numbers: 863-70

Journal Abbreviation: Curr. Eye Res.

ISSN: 0271-3683

DAY: 26

MONTH: Oct

YEAR: 2007

Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. Information

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LANGUAGE: eng

NlmUniqueID: 8104312

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Grant and Affiliation Information for Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis.

AFFILIATION: Department of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan. muratodooru@yahoo.com

Country: England

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MEDLINETA: Curr Eye Res

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