Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease.

Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease. Abstract Text:

BACKGROUND: Coronary arterial lesions (CAL) due to Kawasaki disease (KD) often show progressive intimal hyperplasia even many years after the disease. However, most patients have no CAL after the acute phase, and it is an important issue whether or not coronary arteries without CAL have significant intimal hyperplasia, and whether or not there is the potential for this to progress to stenosis and/or atherosclerosis. METHODS: The authors examined formalin-fixed specimens of the coronary arteries immunohistochemically, using antibodies against vascular growth factors (GFs), the receptors of transforming growth factor-beta (TbetaRs) and inducible nitric oxid synthesis (iNOS) in a KD patient without CAL, and also in four control patients: two with CAL due to KD and two without a history of KD. RESULTS: Vascular endothelial GFs, Platelet-derived growth factor-A (PDGF-A) and TbetaRs were expressed in the vascular smooth muscle cells of all patients. PDGF-A, transforming Gfbeta1 and iNOS were expressed in the intimal smooth muscle cells of the KD but not the normal coronary artery without a history of KD. The number of TbetaR-II-positive cells were fewer than TbetaR-I-positive cells in the intima of CAL due to KD, but the number was of both almost same in the intima of coronary artery without CAL after KD and in the normal coronary. CONCLUSION: The intact coronary artery 13 months after KD still showed the influence of the inflammation of KD. Although the authors speculate that the intimal proliferation will not continue beyond the acute phase, those patients may have a risk factor for atherosclerosis.

Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatrics international : official journal of the

VOLUME: 46

Page Numbers: 590-6

Journal Abbreviation: Pediatr Int

ISSN: 1328-8067

DAY: 21

MONTH: Oct

YEAR: 2004

Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100886002

Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor A

MESH TERMS: analysis

Chemical & Substance for Abstract: Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease. Information

Substance Name: Nitric Oxide Synthase Type II

Registry Number: EC 1.14.13.39

Grant and Affiliation Information for Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease.

AFFILIATION: Department of Pediatrics, Tokyo Postal Services Agency Hospital, Tokyo, Japan. asuzuki@tth-japanpost.jp

Country: Australia

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pediatr Int

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease Related Publications

• Elongation in a beta-structure promotes amyloid-like fibril formation of human lysozyme.
• Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease.
• Molecular weight of thermostable alpha-amylase from B. stearothermophilus.
• Recovery of the intact structure of Taka-amylase A after reduction of all disulfide linkages in 8 M urea.
• Stabilization due to dimer formation of phosphoribosyl anthranilate isomerase from Thermus thermophilus HB8: X-ray Analysis and DSC experiments.
• Structure of putative CutA1 from Homo sapiens determined at 2.05 A resolution.
• The confirmation of the denatured structure of pyrrolidone carboxyl peptidase under nondenaturing conditions: difference in helix propensity of two synthetic peptides with single amino acid substitution.
• The structure, stability, and folding process of amyloidogenic mutant human lysozyme.
• [A case report of aortic aneurysm due to aortitis syndrome-surgically treated with extra anatomical bypass]
• [A report of a case of systemic cholesterol embolization after A-C bypass surgery]
• [A surgical case report of aortic aneurysm with rupture into the pulmonary artery (author's transl)]
• [Truncus arteriosus in a thirty-one-year-old man with severe obstructive pulmonary vascular disease: a case report of successful surgical correction (author's transl)]