Immunohistochemical observations of antigen presenting cells and follicular dendritic cells in the tonsil.

Immunohistochemical observations of antigen presenting cells and follicular dendritic cells in the tonsil. Research Abstract Details 

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Immunohistochemical observations of antigen presenting cells and follicular dendritic cells in the tonsil. Abstract Text:

T Torigoe,T Urushibata,M Ishikura,I Takeyama,

In the present study, in order to investigate the behavior in the lymphatic system of phagocytic cells which incorporate potential antigen in the tonsile crypt, the distribution of HRP stained macrophages in the tonsillar system was observed with regard to changes with time. Furthermore, in the tonsillar tissue, in order to investigate the relationship among HRP marked macrophages, follicular dendritic cells and adhesion molecules, such as ICAM-1, immunological double staining was performed. It is open to discussion whether ICAM-1 plays an important role as an adhesive molecule in this migration of macrophages. Immunohistochemical double staining method detected a relation between anti-ICAM-1 antibody positive cells and antigen stained macrophages. In the stained area between anti-ICAM-1 antibodies and anti-DRC-1 antibodies, positive cells were clearly observed to have reticular form, particularly in the mature germinal center. This phenomenon implies that dendritic cells express ICAM-1 on the cell surface to contact other immunorelated cells and/or substances. In the inter-follicular space, anti-ICAM-1 antibody positive cells were observed to form a cluster composed of ICAM-1 positive cells, lymphocytes and HRP stained macrophages. This cluster may be considered the most primary stage of follicles or as triggering the creation of an inmature follicle.

Immunohistochemical observations of antigen presenting cells and follicular dendritic cells in the tonsil. Publishing Authors By Initials

T Torigoe,T Urushibata,M Ishikura,I Takeyama,

For similar stomatognathic diseases: pharyngeal diseases: tonsillitis research abstracts see: stomatognathic diseases: pharyngeal diseases: tonsillitis research

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Immunohistochemical observations of antigen presenting cells and follicular dendritic cells in the tonsil. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta oto-laryngologica. Supplementum

VOLUME: 522

Page Numbers: 74-8

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: 02

YEAR: 1996

Immunohistochemical observations of antigen presenting cells and follicular dendritic cells in the tonsil. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Immunohistochemical observations of antigen presenting cells and follicular dendritic cells in the tonsil. Keywords Mesh Terms:

KEYWORDS: Tonsillitis

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Immunohistochemical observations of antigen presenting cells and follicular dendritic cells in the tonsil. Information

Substance Name: Cell Adhesion Molecules

Registry Number: 0

Grant and Affiliation Information for Immunohistochemical observations of antigen presenting cells and follicular dendritic cells in the tonsil.

AFFILIATION: Department of Otolaryngology, St. Marianna University School of Medicine, Kawasaki, Japan.

Country: NORWAY

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MEDLINETA: Acta Otolaryngol Suppl

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