Immunohistochemical estrogen receptor determination in human breast carcinoma: correlation with histologic differentiation and age of the patients.

Immunohistochemical estrogen receptor determination in human breast carcinoma: correlation with histologic differentiation and age of the patients. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Immunohistochemical estrogen receptor determination in human breast carcinoma: correlation with histologic differentiation and age of the patients. Abstract Text:

S Pervez,H Shaikh,F Aijaz,S A Aziz,M Naqvi,S H Hasan,

An immunohistochemical assay for the measurement of estrogen receptor (ER) has been evaluated on 290 consecutive human breast biopsy and mastectomy specimens in the year 1992 at The Aga Khan University Hospital laboratories. Immunohistochemical localization of estrogen receptor on frozen/paraffin section was scored in a semi-quantitative fashion incorporating both the intensity and the distribution of specific staining. Histologic grading of the tumour was performed according to Bloom's method. In this study, 21% of the tumours were estrogen receptor negative, 15% were weak positive, 25% intermediate positive and 39% strong positive. Fifty percent of the well differentiated tumours showed strong ER positivity against 27% of the poorly differentiated tumours. Seventy eight percent of all negative estrogen receptors were in patients younger than 50 years of age (pre-menopausal group), while 52% of strong estrogen receptor positivity was observed in patients older than 50 years (post- menopausal). This study demonstrates the value of immunohistochemical method to determine the ER status in patients with advanced breast cancer.

Immunohistochemical estrogen receptor determination in human breast carcinoma: correlation with histologic differentiation and age of the patients. Publishing Authors By Initials

S Pervez,H Shaikh,F Aijaz,SA Aziz,M Naqvi,SH Hasan,

For similar proteins: receptors, cytoplasmic and nuclear: receptors, steroid: receptors, estrogen research abstracts see: proteins: receptors, cytoplasmic and nuclear: receptors, steroid: receptors, estrogen research

PUBMED ID PMID:

MEDLINE DATE:

Immunohistochemical estrogen receptor determination in human breast carcinoma: correlation with histologic differentiation and age of the patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: JPMA. The Journal of the Pakistan Medical Associat

VOLUME: 44

Page Numbers: 133-6

Journal Abbreviation:

ISSN: 0030-9982

DAY: 12

MONTH: Jun

YEAR: 1994

Immunohistochemical estrogen receptor determination in human breast carcinoma: correlation with histologic differentiation and age of the patients. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7501162

Immunohistochemical estrogen receptor determination in human breast carcinoma: correlation with histologic differentiation and age of the patients. Keywords Mesh Terms:

KEYWORDS: Receptors, Estrogen

MESH TERMS: analysis

Chemical & Substance for Abstract: Immunohistochemical estrogen receptor determination in human breast carcinoma: correlation with histologic differentiation and age of the patients. Information

Substance Name: Receptors, Estrogen

Registry Number: 0

Grant and Affiliation Information for Immunohistochemical estrogen receptor determination in human breast carcinoma: correlation with histologic differentiation and age of the patients.

AFFILIATION: Department of Pathology, Aga Khan University Hospital, Karachi.

Country: PAKISTAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Pak Med Assoc

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Immunohistochemical estrogen receptor determination in human breast carcinoma: correlation with histologic differentiation and age of the patients Related Publications

• A framework for quality control and parameter optimization in diffusion tensor imaging: theoretical analysis and validation.
• A mechanism-based combination therapy reduces local tumor growth and metastasis in an orthotopic model of prostate cancer.
• A rare actinomycosis of humerus: an unusual location and a diagnostic dilemma. A case report.
• Absorbed photodynamic dose from pulsed versus continuous wave light examined with tissue-simulating dosimeters.
• Chemotherapeutic/chemopreventive role of retinoids in chemically induced skin carcinogenesis in albino mice.
• Clinico-morphological pattern and frequency of bone cancer.
• Comparative study of endoscopic band ligation and sclerotherapy for treatment of oesophageal varices in cirrhotic patients.
• Dengue outbreak in Karachi, Pakistan, 2006: experience at a tertiary care center.
• Diabetic nephropathy in childhood and adolescence.
• Diagnosis of perimesencephalic nonaneurysmal subarachnoid hemorrhage with computed tomography.
• Fine needle aspiration cytology (FNAC) in the management of thyroid pathology--the Aga Khan University Hospital experience.
• Focal spinal stenosis from vertebral fracture in epileptics.
• Hypertension in children with ambiguous genitalia: six cases.
• Molecular Analysis of CAG Repeats at Five Different Spinocerebellar Ataxia loci: Correlation and Alternative Explanations for Disease Pathogenesis.
• Morphological pattern and frequency of thyroid tumors.
• Multicenter experience of ABO-incompatible pediatric cardiac transplantation.
• Photodynamic therapy for cutaneous leishmaniasis: the effectiveness of topical phenothiaziniums in parasite eradication and Th1 immune response stimulation.
• Preliminary antinociceptive, antioxidant and cytotoxic activities of Leucas aspera root.
• Real-time fluorescence monitoring of phenothiazinium photosensitizers and their anti-mycobacterial photodynamic activity against Mycobacterium bovis BCG in in vitro and in vivo models of localized infection.
• Role of shigella infection in endometriosis: A novel hypothesis.
• Spinal cord compression caused by metastatic epithelial myoepithelial carcinoma of the parotid gland.
• Strategies for enhanced photodynamic therapy effects.
• Targeted photodynamic therapy.
• The effects of Ramadan fasting on certain biochemical parameters in normal subjects and in type II diabetic patients.
• The pattern of malignancies in Karachi (1995 to 1996).
• The use of intra aortic baloon pump in patients undergoing coronary artery bypass grafting at the Aga Khan University Hospital, Karachi.
• Thymoma : a clinicopathologic association of world health organization histologic subtype and invasive behaviour.
• Tumor cell lines resistant to ALA-mediated photodynamic therapy and possible tools to target surviving cells.
• Vascular and cellular targeting for photodynamic therapy.
• p53 and PCNA expression in benign, atypical and malignant meningiomas.