Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms.

Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms. Research Abstract Details 

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Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms. Abstract Text:

Mitsuaki Ishida,Ryoji Kushima,Tokuhiro Chano,Hidetoshi Okabe,

Peripherin is a type III neuronal intermediate filament and its expression is involved in the growth and development of the peripheral nervous systems. Peripherin expression has been reported in cutaneous endocrine carcinomas, but not in rectal well-differentiated endocrine neoplasms (carcinoid tumors). Well-differentiated endocrine neoplasms have been reported to have a relatively high incidence of metastasis, but there is no complete parameter for prediction of their malignant behavior. The aim of the present study was to clarify the expression of peripherin in human fetal and adult rectal mucosae and rectal well-differentiated endocrine neoplasms and the significance of peripherin expression in well-differentiated endocrine neoplasms. Expression of peripherin was studied immunohistochemically in 3 fetal hindgut mucosae, 10 non-neoplastic rectal mucosae, 12 rectal well-differentiated endocrine neoplasms without metastases, and 5 well-differentiated endocrine neoplasms with metastases. Adult rectal mucosal epithelial cells did not have peripherin. However, transient expression of peripherin was detected in the subgroup of epithelial cells of the fetal rectum. Peripherin was demonstrated in all of the rectal well-differentiated endocrine neoplasms without metastases (12/12 cases), but was absent from some of the well-differentiated endocrine neoplasms with metastases (3/5 cases). Constant expression of peripherin in rectal well-differentiated endocrine neoplasms without metastases (12/12) seems to reflect the phenotype of the subpopulation of epithelial cells confined to the fetal rectum. However, loss of its expression was observed in cases with metastases (3/5) and can be regarded as an additional parameter to predict the risk of metastasis in rectal well-differentiated endocrine neoplasms.

Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms. Publishing Authors By Initials

M Ishida,R Kushima,T Chano,H Okabe,

For similar neoplasms: neoplasms by site: digestive system neoplasms: gastrointestinal neoplasms: intestinal neoplasms: colorectal neoplasms: rectal neoplasms research abstracts see: neoplasms: neoplasms by site: digestive system neoplasms: gastrointestinal neoplasms: intestinal neoplasms: colorectal neoplasms: rectal neoplasms research

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Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oncology reports

VOLUME: 18

Page Numbers: 633-7

Journal Abbreviation: Oncol. Rep.

ISSN: 1021-335X

DAY: 28

MONTH: Sep

YEAR: 2007

Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms. Information

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LANGUAGE: eng

NlmUniqueID: 9422756

Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms. Keywords Mesh Terms:

KEYWORDS: Rectal Neoplasms

MESH TERMS: surgery

Chemical & Substance for Abstract: Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms. Information

Substance Name: peripherin

Registry Number: 0

Grant and Affiliation Information for Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms.

AFFILIATION: Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan.

Country: Greece

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MEDLINETA: Oncol Rep

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