Immunoglobulins and albumin in sputum from patients with cystic fibrosis. A study of protein stability and presence of proteases.

Immunoglobulins and albumin in sputum from patients with cystic fibrosis. A study of protein stability and presence of proteases. Research Abstract Details 

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Immunoglobulins and albumin in sputum from patients with cystic fibrosis. A study of protein stability and presence of proteases. Abstract Text:

Sputum sol phase from seventeen cystic fibrosis (CF) patients chronically infected in the lungs with mucoid Pseudomonas aeruginosa and presenting multiple precipitins in serum against this bacterium (CF + P) and 11 CF patients without P. aeruginosa infection (CF-P) were examined for proteolytic activity in a fibrin plate assay. The proteolytic activity was significantly higher (p smaller than 0.02) in sputum from CF + P patients than in sputum from CF-patients. This difference was only quantitative since sputum sol phase from both groups degraded fibrinogen to non-precipitable material. The proteolytic degradation of IgG, IgA, secretory IgA and albumin in the sputum sol phases was investigated by means of gel filtration and the stability of these proteins during various storage conditions was examined. Degradation of IgG, IgA, secretory IgA and albumin in the sputa was not demonstrable and the proteins were stable for at least 4 weeks at 4 degree C.

Immunoglobulins and albumin in sputum from patients with cystic fibrosis. A study of protein stability and presence of proteases. Publishing Authors By Initials

For similar fluids and secretions: bodily secretions: sputum research abstracts see: fluids and secretions: bodily secretions: sputum research

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Immunoglobulins and albumin in sputum from patients with cystic fibrosis. A study of protein stability and presence of proteases. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta pathologica et microbiologica Scandinavica. S

VOLUME: 88

Page Numbers: 275-80

Journal Abbreviation:

ISSN: 0304-1328

DAY: 26

MONTH: Oct

YEAR: 1980

Immunoglobulins and albumin in sputum from patients with cystic fibrosis. A study of protein stability and presence of proteases. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7508469

Immunoglobulins and albumin in sputum from patients with cystic fibrosis. A study of protein stability and presence of proteases. Keywords Mesh Terms:

KEYWORDS: Sputum

MESH TERMS: immunology

Chemical & Substance for Abstract: Immunoglobulins and albumin in sputum from patients with cystic fibrosis. A study of protein stability and presence of proteases. Information

Substance Name: Peptide Hydrolases

Registry Number: EC 3.4.-

Grant and Affiliation Information for Immunoglobulins and albumin in sputum from patients with cystic fibrosis. A study of protein stability and presence of proteases.

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Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Scand [C

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