Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study.

Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study. Abstract Text:

William J Moss,Susana Scott,Nanthalile Mugala,Zaza Ndhlovu,Judy A Beeler,Susette A Audet,Mirriam Ngala,Sheila Mwangala,Chansa Nkonga-Mwangilwa,Judith J Ryon,Mwaka Monze,Francis Kasolo,Thomas C Quinn,Simon Cousens,Diane E Griffin,Felicity T Cutts,

BACKGROUND: Achieving the level of population immunity required for measles elimination may be difficult in regions of high human immunodeficiency virus type 1 (HIV-1) prevalence, because HIV-1-infected children may be less likely to respond to or maintain protective antibody levels after vaccination. METHODS: We conducted a prospective study of the immunogenicity of standard-titer measles vaccine administered at 9 months of age to HIV-1-infected and uninfected children in Lusaka, Zambia. RESULTS: From May 2000 to November 2002, 696 children aged 2-8 months were enrolled. Within 6 months of vaccination, 88% of 50 HIV-1-infected children developed antibody levels of >or=120 mIU/mL, compared with 94% of 98 HIV-seronegative children and 94% of 211 HIV-seropositive but uninfected children (P=.3). By 27 months after vaccination, however, only half of the 18 HIV-1-infected children who survived and returned for follow-up maintained measles antibody levels >or=120 mIU/mL, compared with 89% of 71 uninfected children (P=.001) and in contrast with 92% of 12 HIV-1-infected children revaccinated during a supplemental measles immunization activity. CONCLUSIONS: Although HIV-1-infected children showed good primary antibody responses to measles vaccine, their rapid waning of antibody suggests that measles vaccination campaigns may need to be repeated more frequently in areas of high HIV-1 prevalence.

Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study. Publishing Authors By Initials

WJ Moss,S Scott,N Mugala,Z Ndhlovu,JA Beeler,SA Audet,M Ngala,S Mwangala,C Nkonga-Mwangilwa,JJ Ryon,M Monze,F Kasolo,TC Quinn,S Cousens,DE Griffin,FT Cutts,

For similar geographic locations: africa: africa south of the sahara: africa, southern: zambia research abstracts see: geographic locations: africa: africa south of the sahara: africa, southern: zambia research

PUBMED ID PMID:

MEDLINE DATE:

Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of infectious diseases

VOLUME: 196

Page Numbers: 347-55

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 19

MONTH: 06

YEAR: 2007

Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413675

Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study. Keywords Mesh Terms:

KEYWORDS: Zambia

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study. Information

Substance Name: Measles Vaccine

Registry Number: 0

Grant and Affiliation Information for Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study.

AFFILIATION: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA. wmoss@jhsph.edu

Country: United States

AGENCY: United Kingdom Wellcome T

GRANT: gr059114ma

ACRONYM: AI

MEDLINETA: J Infect Dis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study Related Publications

• A brief indicator of household energy security: associations with food security, child health, and child development in US infants and toddlers.
• C-reactive protein and procalcitonin in the evaluation of the efficacy of a pneumococcal conjugate vaccine in Gambian children.
• Chapter 15: HPV vaccine use in the developing world.
• Epidemiology and clinical features of pneumonia according to radiographic findings in Gambian children.
• Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets.
• HIV type 1 infection is a risk factor for mortality in hospitalized Zambian children with measles.
• Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study.
• Pneumonia not responding to penicillin.
• The influence of HIV-1 exposure and infection on levels of passively acquired antibodies to measles virus in Zambian infants.