Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques.

Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques. Research Abstract Details 

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Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques. Abstract Text:

Human metapneumovirus (HMPV) is an important cause of acute respiratory tract disease for which the development of vaccine candidates is warranted. We have previously described the generation of an iscom matrix-adjuvanted HMPV fusion protein subunit vaccine (Fsol) and a live-attenuated vaccine (HMPV(M11)). Here, we evaluate the immunogenicity and efficacy of these vaccines in cynomolgus macaques. Immunization with Fsol induced HMPV F-specific antibody responses, virus neutralizing antibody titers, and cellular immune responses, but the induced humoral immune response waned rapidly over time. HMPV(M11) was strongly attenuated and displayed limited immunogenicity, although immunization with this virus primed for a good secondary HMPV-specific lymphoproliferative response after challenge infection. The duration of virus shedding in HMPV(M11)-immunized animals was reduced compared to sham-immunized animals. Both vaccines induced HMPV-specific immune responses, but the rapid waning of immunity is a challenging obstacle for vaccine development.

Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques. Publishing Authors By Initials

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Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vaccine

VOLUME: 26

Page Numbers: 4224-30

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 6

MONTH: 06

YEAR: 2008

Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques. Information

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LANGUAGE: eng

NlmUniqueID: 8406899

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Grant and Affiliation Information for Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques.

AFFILIATION: Department of Virology, Erasmus MC, Rotterdam, The Netherlands.

Country: Netherlands

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MEDLINETA: Vaccine

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