Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model.

Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model. Research Abstract Details 

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Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model. Abstract Text:

Jinshu Xu,Zheng Zhu,Jie Wu,Wentao Liu,Xiangchun Shen,Yin Zhang,Zhuoyi Hu,Dongya Zhu,Rouel S Roque,Jingjing Liu,

We have previously shown that anti-GnRH antibodies responses can be induced by synthetic GnRH3-hinge-MVP peptide. In this study, GnRH3-hinge-MVP of conjugation to heat shock protein 65 was used as an adjuvant-free vaccine to assess the therapeutic effects of GnRH immunoneutralisation on tumor development in the mice model. Compared with mice treated with Hsp65 and PBS, mice of the o.t. model receiving in situ treatment GnRH3-hinge-MVP-Hsp65 had significant prolongation of survival and suppression of local tumor growth. Serum levels of both testosterone and luteinizing hormone were reduced by treatment with GnRH3-hinge-MVP-Hsp65 (p<0.05). Further analyses of cell mediated immune responses showed that GnRH3-hinge-MVP-Hsp65 induced stronger lymphocyte proliferative responses and higher levels of IFN-gamma (p<0.001). The conjugation of the recombinant GnRH peptide to Hsp65 could be considered a promising approach for the development of an efficacious vaccine against the prostate cancer.

Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model. Publishing Authors By Initials

J Xu,Z Zhu,J Wu,W Liu,X Shen,Y Zhang,Z Hu,D Zhu,RS Roque,J Liu,

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Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer letters

VOLUME: 259

Page Numbers: 240-50

Journal Abbreviation: Cancer Lett.

ISSN: 0304-3835

DAY: 26

MONTH: 11

YEAR: 2007

Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model. Information

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LANGUAGE: eng

NlmUniqueID: 7600053

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Grant and Affiliation Information for Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model.

AFFILIATION: School of Pharmacy, Nanjing Medical University, Nanjing, PR China; The Minigene Pharmacy Laboratory, Biopharmaceutical College, China Pharmaceutical University, Nanjing, PR China.

Country: Ireland

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MEDLINETA: Cancer Lett

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