Immunization of rats with cholinergic neurons induces behavioral deficits.

Immunization of rats with cholinergic neurons induces behavioral deficits. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Immunization of rats with cholinergic neurons induces behavioral deficits. Abstract Text:

We have previously shown that sera from patients with Alzheimer's disease (AD) contain a significantly high level of antibodies to the cell bodies (Perikarya; PK) but not to the nerve terminals (synaptosomes) of purely cholinergic neurons from the electric fish Torpedo. In the present study we examined the effect of repeated immunization of rats with either of these antigens for one year. Immunoblot studies revealed that sera of cholinergic PK immunized rats contained a high level of antibodies to cholinergic PK proteins, in particular to a 200 kilodalton protein, to which there are specifically high levels of antibodies in AD. Sera from rats immunized with cholinergic synaptosomes and from control rats contained very low levels of these antibodies. Behavioral studies performed one year after the initial immunization revealed that the cholinergic PK immunized rats were impaired in spatial learning and memory tasks (Morris swim test and T-maze alternation) when compared to control rats and that the synaptosome-immunized rats showed no such deficit. In contrast, the three groups performed similarly in general activity, active avoidance and conditioned emotional response tests. Further experiments revealed that the cholinergic PK immunized rats displayed a significant deficit in short term memory. The association of antibodies to cholinergic neurons with cognitive deficits in this rat model suggests that such antibodies may be involved in the pathogenesis of AD.

Immunization of rats with cholinergic neurons induces behavioral deficits. Publishing Authors By Initials

For similar animals: chordata: vertebrates: fishes: elasmobranchii: torpedo research abstracts see: animals: chordata: vertebrates: fishes: elasmobranchii: torpedo research

PUBMED ID PMID:

MEDLINE DATE:

Immunization of rats with cholinergic neurons induces behavioral deficits. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neural transplantation

VOLUME: 1

Page Numbers: 63-76

Journal Abbreviation:

ISSN: 1352-237X

DAY: 17

MONTH: 03

YEAR: 1989

Immunization of rats with cholinergic neurons induces behavioral deficits. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9104162

Immunization of rats with cholinergic neurons induces behavioral deficits. Keywords Mesh Terms:

KEYWORDS: Torpedo

MESH TERMS: immunology

Chemical & Substance for Abstract: Immunization of rats with cholinergic neurons induces behavioral deficits. Information

Substance Name: Acetylcholinesterase

Registry Number: EC 3.1.1.7

Grant and Affiliation Information for Immunization of rats with cholinergic neurons induces behavioral deficits.

AFFILIATION: Department of Biochemistry, George S. Wise Faculty of Life Sciences, Ramat Aviv, Israel.

Country: ENGLAND

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Neural Transplant

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Immunization of rats with cholinergic neurons induces behavioral deficits Related Publications

• "AN ANALYSIS AND FOLLOW-UP OF 301 CASES OF BATTLE CASUALTY INJURY TO THE EYES".
• "ANGINA CAPITIS".
• A CASE OF EXFOLIATION OF THE LENS CAPSULE WITH THE PATHOLOGICAL REPORT.
• A CASE OF PERIVASCULITIS RETINAE ASSOCIATED WITH SYMPTOMS OF CEREBRAL DISEASE.
• A SIMPLE DEVICE FOR TESTING DIPLOPIA.
• A TRIAL SPECTACLE FOR PRISM PRESCRIPTION.
• ANGIOMA OF THE RETINA.
• Activation of the amyloid cascade by intracerebroventricular injection of the protease inhibitor phosphoramidon.
• Activation of the amyloid cascade in apolipoprotein e4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits.
• Blood-vessel formation in the cornea.
• DARK ADAPTATION IN DETECTING VITAMIN ;A' DEFICIENCY.
• DEFECTIVE NIGHT VISION AMONG SOLDIERS; DARK ADAPTATION RESULTS AND THEIR USE IN DIAGNOSIS.
• ENZYMES IN MENTAL RETARDATION.
• ENZYMES IN MENTAL RETARDATION. II.
• EPIDEMIC KERATO-CONJUNCTIVITIS ASSOCIATED WITH SKIN LESIONS.
• Effect of iodide on thyroid glands of rats kept at low temperature.
• Health implications of exposure to radiofrequency/microwave energies.
• INCOMPLETE AVULSION OF THE EYE-REPORT OF A CASE.
• INTRA-MURAL NEW VESSELS IN AN OCCLUDED RETINAL VEIN: A clinical description.
• Immunization of rats with cholinergic neurons induces behavioral deficits.
• Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation.
• Involutionary sclerosis and diastolic hypertension. Effect of environmental change.
• Occupational and individual factors in acute shoulder-neck disorders among industrial workers.
• Proliferation of limbal melanoblasts into the cornea in response to a corneal lesion; an experimental study.
• RETINAL ARTERY OCCLUSION: A Report Illustrating the Pathogenesis of the Fundal Appearances and the effect of Acetyl-choline.
• Retinal neovascularisation: early contributions of Professor Michaelson and recent observations.
• Severe leukemoid reaction after promazine-induced agranulocytosis.
• THE CHEMICAL COMPOSITION OF THE HUMAN VITREOUS BODY AS RELATED TO AGE AND MYOPIA.
• TRANSCLERAL DIVISION OF MID-VITREOUS MEMBRANE UNDER VISUAL CONTROL.
• Total replacement of the hip for avascular necrosis in sickle cell disease.