Immune tolerance: mechanisms and application in clinical transplantation.

Immune tolerance: mechanisms and application in clinical transplantation. Research Abstract Details 

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Immune tolerance: mechanisms and application in clinical transplantation. Abstract Text:

M Sykes,

The achievement of immune tolerance, a state of specific unresponsiveness to the donor graft, has the potential to overcome the current major limitations to progress in organ transplantation, namely late graft loss, organ shortage and the toxicities of chronic nonspecific immumnosuppressive therapy. Advances in our understanding of immunological processes, mechanisms of rejection and tolerance have led to encouraging developments in animal models, which are just beginning to be translated into clinical pilot studies. These advances are reviewed here and the appropriate timing for clinical trials is discussed.

Immune tolerance: mechanisms and application in clinical transplantation. Publishing Authors By Initials

M Sykes,

For similar biological phenomena, cell phenomena, and immunity: immunity: immune tolerance: transplantation tolerance research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: immune tolerance: transplantation tolerance research

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Immune tolerance: mechanisms and application in clinical transplantation. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of internal medicine

VOLUME: 262

Page Numbers: 288-310

Journal Abbreviation: J. Intern. Med.

ISSN: 0954-6820

DAY: 3

MONTH: Sep

YEAR: 2007

Immune tolerance: mechanisms and application in clinical transplantation. Information

Number of References: 260

LANGUAGE: eng

NlmUniqueID: 8904841

Immune tolerance: mechanisms and application in clinical transplantation. Keywords Mesh Terms:

KEYWORDS: Transplantation Tolerance

MESH TERMS: immunology

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Grant and Affiliation Information for Immune tolerance: mechanisms and application in clinical transplantation.

AFFILIATION: Transplantation Biology Research Center, Bone Marrow Transplantation Section, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA. megan.sykes@tbrc.mgh.harvard.edu

Country: England

AGENCY: United States NHLBI

GRANT: R01 HL49915

ACRONYM: HL

MEDLINETA: J Intern Med

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