Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults.

Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. Research Abstract Details 

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Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. Abstract Text:

John Treanor,Hulin Wu,Hua Liang,David J Topham,

The kinetics and frequency of the primary response to human smallpox vaccine was compared to that among subjects re-vaccinated within the last 2 years, or after several decades. Vaccination induced local and systemic reactions that were mildest in the distant cohort and more severe in the primary vaccinees. The timing of IFN-gamma responses was similar in all three groups, but of higher frequency in the primary vaccinees. Responses to vaccinia re-immunization between those immunized <2 years ago and those immunized >10 years ago were not significantly different. Neutralizing antibodies were boosted in all groups, with the highest titers observed among the distant cohort. However, the antibody and IFN-gamma responses did not correlate strongly with the local reactions at the vaccine site. This suggests that local immune events in the tissue are distinct from the parameters measured in the peripheral blood.

Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. Publishing Authors By Initials

J Treanor,H Wu,H Liang,DJ Topham,

For similar viruses: dna viruses: poxviridae: chordopoxvirinae: orthopoxvirus: vaccinia virus research abstracts see: viruses: dna viruses: poxviridae: chordopoxvirinae: orthopoxvirus: vaccinia virus research

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MEDLINE DATE:

Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Vaccine

VOLUME: 24

Page Numbers: 6913-23

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 21

MONTH: 06

YEAR: 2006

Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8406899

Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. Keywords Mesh Terms:

KEYWORDS: Vaccinia virus

MESH TERMS: immunology

Chemical & Substance for Abstract: Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults.

AFFILIATION: Department of Medicine, Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY 14642, USA.

Country: Netherlands

AGENCY: United States NCRR

GRANT: RR00044

ACRONYM: RR

MEDLINETA: Vaccine

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